Journal
CHEMICAL SCIENCE
Volume 13, Issue 18, Pages 5085-5106Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc05478c
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Funding
- Natural Science Foundation of China [22122701, 21731004, 21907050, 91953201, 21907044, 92153303]
- Natural Science Foundation of Jiangsu Province [BK20190282, BK20202004]
- Excellent Research Program of Nanjing University [ZYJH004]
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This review highlights recent advancements in the development of noble metal complex photosensitizers for photodynamic therapy (PDT) during the last 5 years. It summarizes the design strategies of noble metal complexes for efficient and precise PDT, as well as discusses the limitations and future perspectives of such photosensitizers in clinical applications.
Photodynamic therapy (PDT) utilizes light-activated photosensitizers (PSs) to generate toxic species for therapeutics. It has become an emerging solution for cancer treatment because of its specific spatiotemporal selectivity and minimal invasiveness. Noble metal (Ru, Ir and Pt) complexes are of increasing interest as photosensitizers for their excellent photophysical, photochemical, and photobiological properties. In this review, we highlight recent advancements in the development of noble metal complex photosensitizers for PDT during the last 5 years. We will summarize the design strategies of noble metal complexes for efficient and precise PDT, including increasing the light penetration depth, reducing the oxygen-dependent nature and improving target ability. Finally, we summarize recent efforts for the development of noble-based PSs and discuss the limitations of such PSs in clinical application and future perspectives in this field, such as the combination of PDT with other treatment modalities.
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