4.8 Article

The Janus face of high trans-effect carbenes in olefin metathesis: gateway to both productivity and decomposition

Journal

CHEMICAL SCIENCE
Volume 13, Issue 18, Pages 5107-5117

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc00855f

Keywords

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Funding

  1. Natural Sciences and Engineering Research Council of Canada (NSERC)
  2. Research Council of Norway (RCN) [262370, 288135, 226244, NN2506K, NS2506K]
  3. Government of Ontario

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This study investigates the factors promoting or inhibiting β-H elimination in the metathesis of alcohols and styrene using silicon-cyclic (alkyl)(amino)carbene (CAAC) catalysts and N-heterocyclic carbene (NHC) catalysts. The results show that CAAC catalysts have a stronger trans effect, which inhibits β-H elimination. However, the strong trans effect of CAAC catalysts also accelerates other decomposition pathways of the catalyst.
Ruthenium-cyclic(alkyl)(amino)carbene (CAAC) catalysts, used at ppm levels, can enable dramatically higher productivities in olefin metathesis than their N-heterocyclic carbene (NHC) predecessors. A key reason is the reduced susceptibility of the metallacyclobutane (MCB) intermediate to decomposition via beta-H elimination. The factors responsible for promoting or inhibiting beta-H elimination are explored via density functional theory (DFT) calculations, in metathesis of ethylene or styrene (a representative 1-olefin) by Ru-CAAC and Ru-NHC catalysts. Natural bond orbital analysis of the frontier orbitals confirms the greater strength of the orbital interactions for the CAAC species, and the consequent increase in the carbene trans influence and trans effect. The higher trans effect of the CAAC ligands inhibits beta-H elimination by destabilizing the transition state (TS) for decomposition, in which an agostic MCB C-beta-H bond is positioned trans to the carbene. Unproductive cycling with ethylene is also curbed, because ethylene is trans to the carbene ligand in the square pyramidal TS for ethylene metathesis. In contrast, metathesis of styrene proceeds via a 'late' TS with approximately trigonal bipyramidal geometry, in which carbene trans effects are reduced. Importantly, however, the positive impact of a strong trans-effect ligand in limiting beta-H elimination is offset by its potent accelerating effect on bimolecular coupling, a major competing means of catalyst decomposition. These two decomposition pathways, known for decades to limit productivity in olefin metathesis, are revealed as distinct, antinomic, responses to a single underlying phenomenon. Reconciling these opposing effects emerges as a clear priority for design of robust, high-performing catalysts.

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