4.4 Article

A novel approach to studying early knee osteoarthritis illustrates that bilateral medial tibiofemoral osteoarthritis is a heritable phenotype: an offspring study

Journal

RHEUMATOLOGY INTERNATIONAL
Volume 42, Issue 6, Pages 1063-1072

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s00296-022-05116-1

Keywords

Knee; Osteoarthritis; Offspring; Heritability

Categories

Funding

  1. NIH/NIAMS [R03AR069323]
  2. National Institutes of Health, a branch of the Department of Health and Human Services [CIN 13-413, N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262]
  3. Merck Research Laboratories
  4. Novartis Pharmaceuticals Corporation
  5. Pfizer Inc.
  6. National Institutes of Health [5 TL1 TR 1454-3]
  7. GlaxoSmithKline

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This study assessed the potential of studying offspring of people with and without knee osteoarthritis to understand the risk factors and heritability for knee osteoarthritis. The results showed that parental obesity, hypertension, and Heberden's nodes were associated with osteoarthritis status, and offspring with parental osteoarthritis status had higher rates of radiographic tibiofemoral osteoarthritis and meniscal abnormalities.
To assess the potential of studying offspring of people with and without knee osteoarthritis to understand the risk factors and heritability for knee osteoarthritis. We selected two groups of Osteoarthritis Initiative (OAI) participants from one clinical site: (1) participants with bilateral radiographic medial tibiofemoral osteoarthritis and (2) those without tibiofemoral osteoarthritis. We then invited biological offspring >= 18 years old to complete an online survey that inquired about osteoarthritis risk factors and symptoms. Among the survey respondents, we recruited ten offspring of members from each group for a clinic visit with bilateral knee posterior-anterior radiographs and magnetic resonance imaging of the right knee. We established contact with 269/413 (65%) eligible OAI participants. Most (227/269, 84%) had >= 1 eligible biological offspring, and 213 (94%) were willing to share information about the new family study with their offspring. Our survey was completed by 188 offspring from 110 OAI participants: mean age of 43.0 (10.4) years, mean body mass index of 23.7 (5.9) kg/m(2), 65% female. Offspring obesity (OR = 2.7, 95% CI 1.0-7.3), hypertension (OR = 3.7, 95% CI 1.2-11.3), and Heberden's nodes (OR = 3.6, 95% CI 1.0-13.2) were associated with parental osteoarthritis status; however, adjusted models were not statistically significant. Radiographic tibiofemoral osteoarthritis (16/18 knees vs. 2/20 knees) and meniscal abnormalities (7/9 vs. 2/10 index knees) were more common among offspring with parental osteoarthritis status than not. We established the potential of a novel offspring study design within the OAI, and our results are consistent with bilateral radiographic medial tibiofemoral osteoarthritis being a heritable phenotype of osteoarthritis.

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