Propofol Reduces Renal Ischemia Reperfusion-mediated Necroptosis by Up-regulation of SIRT1 in Rats

Article Chemistry, Multidisciplinary

Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis

Fang Wang et al.

Summary: The study demonstrates that SFN enhances programmed cell death and inflammation caused by cisplatin or I/R via interacting with RIPK3, suggesting it may serve as a promising therapeutic target for AKI treatment.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Physiology

Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury

Mark Hepokoski et al.

Summary: Acute kidney injury has been shown to impact lung metabolism and lead to lung injury, with alterations in mitochondrial function and mtDAMPs correlating with these metabolic changes. Mitochondrial function and mtDAMPs are potential therapeutic targets in preventing lung injury due to AKI.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

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Article Surgery

Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma

Ben E. Biesterveld et al.

Summary: Trauma is a leading cause of death among young people, and valproic acid treatment has been shown to improve survival in animal models of lethal trauma and attenuate the degree of acute kidney injury.

JOURNAL OF SURGICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Ameliorative effect of umbelliferone in remote organ injury induced by renal ischemia-reperfusion in rats

Feyza Icoglu Aksakal et al.

Summary: This study demonstrates that umbelliferone can alleviate kidney, heart, and lung damages caused by renal ischemia/reperfusion (I/R) by suppressing oxidative stress and modulating inflammatory responses. Umbelliferone pretreatment increases levels of SOD, GSH, and eNOS, while decreasing levels of MDA, MPO, TNF-alpha, and IL-6 in remote organ injury induced by renal I/R. Umbelliferone shows potent antioxidant and anti-inflammatory activity in remote organ damages caused by renal I/R, suggesting it as a potential therapeutic agent for treating such damages.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Immunology

Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest

Wen-yan Wang et al.

Summary: The ERK/calpain-2 signaling pathway plays a crucial role in regulating inflammation and necroptosis in cerebral ischemia-reperfusion injury after cardiac arrest. Inhibition of this pathway can improve brain function and suppress inflammatory responses and necroptosis in the rat model of cardiac arrest-induced CIRI.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR-126-5p axis

Xuyang Li et al.

Summary: The study found that PPF pre-treatment significantly reduced creatinine and urea nitrogen levels in the serum of BALB/c mice with RIRI, and decreased the apoptosis of HK-2 cells treated with H/R. Additionally, PPF pre-treatment markedly inhibited the expression of MALAT1 in both in vivo and in vitro models and upregulated miR-126-5p expression. MALAT1 could adsorb miR-126-5p to repress it and upregulated VEGFA.

JOURNAL OF GENE MEDICINE (2021)

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Article Cell Biology

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

Matija Zelic et al.

Summary: The study highlights the crucial role of RIPK1 in the progression of multiple sclerosis (MS), particularly its impact on microglia. It elucidates the mechanisms by which RIPK1 contributes to MS pathogenesis and confirms its regulatory role in the neuroinflammatory environment. Additionally, the research demonstrates that RIPK1 inhibition in a murine MS model can attenuate disease progression and suppress deleterious signaling in astrocytes and microglia.

CELL REPORTS (2021)

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Article Medicine, General & Internal

Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats

He Tai et al.

Summary: This study investigated whether the combination of TIIA and CsA could alleviate lung apoptosis in obese rats induced by renal IR by regulating mitochondrial function through the PI3K/Akt/Bad pathway. The results showed that the combination of TIIA and CsA effectively reduced lung apoptosis in obese rats.

FRONTIERS IN MEDICINE (2021)

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Article Immunology

Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

Nikos Oikonomou et al.

Summary: Regulation of epithelial cell death plays a key role in controlling immune homeostasis in barrier surfaces. Necroptosis, induced by RIPK3, contributes to inflammatory pathologies in different tissues. Genetic inhibition of RIPK1 kinase activity can prevent the development of exaggerated allergic airway inflammation.

MUCOSAL IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Necrostatin-1 Analog DIMO Exerts Cardioprotective Effect against Ischemia Reperfusion Injury by Suppressing Necroptosis via Autophagic Pathway in Rats

Shigang Qiao et al.

Summary: This study showed that DIMO exerts cardioprotection against myocardial I/R injury by reducing RIP1K activation and restoring impaired autophagic flux.

PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences