4.7 Review

Plant biosynthetic gene clusters in the context of metabolic evolution

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Dissecting the labdane-related diterpenoid biosynthetic gene clusters in rice reveals directional cross-cluster phytotoxicity

Riqing Li et al.

Summary: This study used CRISPR/Cas9 technology to precisely delete two biosynthetic gene clusters related to labdane-related diterpenoids in rice, showing that deletion of one cluster leads to a lesion mimic phenotype while deletion of the other does not. This demonstrates directional cross-cluster interactions between these two gene clusters.

NEW PHYTOLOGIST (2022)

Review Genetics & Heredity

Evolution of polygenic traits under global vs local adaptation

Sam Yeaman

Summary: Observations of alleles associated with complex traits should be interpreted in the context of evolutionary processes. Genetic architecture can significantly impact evolutionary outcomes and provide insights into how evolution works. Local adaptation can lead to concentrated genetic architectures enriched for alleles of larger effect, but evolution of such architectures may be limited by various factors.

GENETICS (2022)

Article Biochemistry & Molecular Biology

Rerouting plant terpene biosynthesis enables momilactone pathway elucidation

Ricardo de la Pena et al.

Summary: The study successfully revealed a complete biosynthetic pathway to momilactones by conducting gene screening in Nicotiana benthamiana and significantly increasing their production yield. In addition to validating the inhibitory activity of momilactones, similar success was achieved in the production of other compounds by applying the same approach.

NATURE CHEMICAL BIOLOGY (2021)

Review Plant Sciences

ERF Gene Clusters: Working Together to Regulate Metabolism

Tsubasa Shoji et al.

Summary: Plants produce structurally diverse specialized metabolites in response to environmental stresses, with the AP2/ERF family of transcription factors playing key roles in regulating biosynthesis. Research has shown that some ERF genes occur in clusters on chromosomes, with jasmonate-responsive ERF gene clusters controlling the biosynthesis of important metabolites.

TRENDS IN PLANT SCIENCE (2021)

Article Plant Sciences

A (conditional) role for labdane-related diterpenoid natural products in rice stomatal closure

Juan Zhang et al.

Summary: Research suggests that labdane-related diterpenoid (LRD) phytoalexins in rice may act as a regulatory switch triggering stomatal closure, thereby affecting drought resistance.

NEW PHYTOLOGIST (2021)

Article Biochemistry & Molecular Biology

Interdependent evolution of biosynthetic gene clusters for momilactone production in rice

Naoki Kitaoka et al.

Summary: Plants may contain biosynthetic gene clusters (BGCs) similar to those found in microbes, but with distinct inheritance patterns due to limited to vertical gene transmission. Rice has two unlinked BGCs involved in diterpenoid phytoalexin metabolism. Genetic evidence has shown that a cytochrome P450 (CYP76M8) from one BGC plays a role in momilactone biosynthesis, highlighting the interdependent evolution of these two BGCs in plants.

PLANT CELL (2021)

Article Multidisciplinary Sciences

Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

Amit Rai et al.

Summary: This study presents the chromosome-level reference and phased genome assembly of Ophiorrhiza pumila, a medicinal plant producing camptothecin, as well as reports on 273 nitrogen-containing metabolites. They propose a working model for MIA evolution and biosynthesis through comparative genomics and analysis of metabolic gene clusters.

NATURE COMMUNICATIONS (2021)

Article Biology

Exploiting genetic diversity and gene synthesis to identify superior nitrogenase NifH protein variants to engineer N2-fixation in plants

Xi Jiang et al.

Summary: By constructing a knowledge-based library and screening, researchers identified superior NifH variants for expression in plant mitochondria and yeast, which could potentially facilitate efficient nitrogen fixation engineering in eukaryotes.

COMMUNICATIONS BIOLOGY (2021)

Review Plant Sciences

Patterns and Processes of Diploidization in Land Plants

Zheng Li et al.

Summary: This review discusses the impact of polyploidy on chromosome pairing behavior in land plants, as well as the two major processes of diploidization: cytological diploidization and genic diploidization/fractionation. It also compares gene fractionation variation across land plants and highlights differences in diploidization between plants and animals.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021 (2021)

Article Multidisciplinary Sciences

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza

Ying Ma et al.

Summary: The study reports the improved genome assembly of Danshen and reveals the possible roles of three CYP71Ds in catalyzing the reactions leading to the formation of the characteristic furan D-ring of tanshinones. The findings shed light on the biosynthetic pathway of tanshinones and highlight the evolutionary origin of different types of diterpenoids in the Lamiaceae family.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway

Xiaofei Yang et al.

Summary: The authors reported the genome assemblies of three Papaver species and the evolution of benzylisoquinoline alkaloids biosynthetic pathway, demonstrating the importance of gene recruitment and structural rearrangements in evolving metabolic pathways.

NATURE COMMUNICATIONS (2021)

Article Plant Sciences

The chromosome-based lavender genome provides new insights into Lamiaceae evolution and terpenoid biosynthesis

Jingrui Li et al.

Summary: This study presented a high-quality reference genome for the Chinese lavender cultivar, revealing expanded gene families related to terpenoid biosynthesis in lavender compared to other species in Lamiaceae. The comprehensive analysis of the genetic basis of volatile production in lavender could serve as a foundation for future research into lavender evolution, phytochemistry, and ecology.

HORTICULTURE RESEARCH (2021)

Review Plant Sciences

Plant Pan-Genomics Comes of Age

Li Lei et al.

Summary: A plant pan-genome is typically larger than the genome of any individual plant, with many genes present in only some genomes. Constructing and interpreting plant pan-genomes is challenging due to the large size and repetitive content of plant genomes. Focus is often on nontransposable element protein coding genes, but noncoding and repetitive DNA also play important roles in genome evolution and phenotype determination.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021 (2021)

Review Plant Sciences

Evolutionary History of Plant Metabolism

Hiroshi A. Maeda et al.

Summary: Plants exhibit tremendous chemical diversity supported by complex biochemical machinery, with metabolic enzymes originating from eukaryotic and prokaryotic ancestors and experiencing high rates of gene duplication and functionalization in land plants. Plants primarily rely on organic carbon generated from CO2 and have undergone few to no gene transfers during their evolutionary history.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021 (2021)

Article Plant Sciences

Rice contains a biosynthetic gene cluster associated with production of the casbane-type diterpenoid phytoalexin ent-10-oxodepressin

Jin Liang et al.

Summary: This study investigated the biosynthesis of ent-10-oxodepressin in rice, identifying the biosynthetic gene cluster (BGC) on chromosome 7 and key enzymes involved in the pathway. Knockout of OsECBS resulted in impaired resistance to the rice fungal blast pathogen, providing potential targets for molecular breeding.

NEW PHYTOLOGIST (2021)

Article Multidisciplinary Sciences

Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe

Wenbing Su et al.

Summary: This study reveals the significant role of whole-genome duplication (WGD) in the evolution of the apple tribe plants, especially in the metabolic diversification of natural products with medicinal properties. Through chromosome-level assemblies and functional characterization analysis, new insights into the genomic basis of medicinal properties have been provided.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals

Yan Li et al.

Summary: Research reveals that the avenacin biosynthetic gene cluster in oats is formed de novo in a subtelomeric region of the genome since oat divergence, lacking homology with other grasses. The order of genes in the cluster is roughly colinear with the biosynthetic pathway, possibly to prevent accumulation of toxic intermediates.

NATURE COMMUNICATIONS (2021)

Article Genetics & Heredity

Genome-Wide Analysis of Terpene Synthase Gene Family in Mentha longifolia and Catalytic Activity Analysis of a Single Terpene Synthase

Zequn Chen et al.

Summary: In this study, the TPS gene family in Mentha longifolia was genome-wide identified and analyzed. A total of 63 TPS genes were identified, which could be divided into six subfamilies. The TPS-b subfamily had the largest number of genes, and the TPS-e subfamily showed significant species-specific expansion in M. longifolia compared to other Lamiaceae plant species.

GENES (2021)

Article Multidisciplinary Sciences

An Oryza-specific hydroxycinnamoyl tyramine gene cluster contributes to enhanced disease resistance

Shuangqian Shen et al.

Summary: A newly discovered hydroxycinnamoyl tyramine (HT) gene cluster in rice plays a crucial role in enhancing resistance to bacterial and fungal pathogens. This cluster, unique to the Oryza AA genome, provides an evolutionary background for accelerating cluster member combinations.

SCIENCE BULLETIN (2021)

Article Biochemistry & Molecular Biology

Polycomb-dependent differential chromatin compartmentalization determines gene coregulation in Arabidopsis

Ying Huang et al.

Summary: The study reveals the crucial role of H3K27me3 in regulating chromatin interactions in plants, showing that reducing H3K27me3 levels can lead to a global reconfiguration of chromatin architecture and impact gene transcription. These findings highlight the tight link between 3D genome organization and reversible histone modifications in governing chromatin interactions.

GENOME RESEARCH (2021)

Review Biochemistry & Molecular Biology

Plant cytochrome P450 plasticity and evolution

Cecilie Cetti Hansen et al.

Summary: The superfamily of cytochrome P450 enzymes is crucial in plant evolution and metabolic diversification. This review provides an overview of the CYP landscape in green algae and land plants, highlighting the key roles played by CYP in plant evolution and metabolism.

MOLECULAR PLANT (2021)

Article Multidisciplinary Sciences

Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids

Yifei Liu et al.

Summary: Chinese goldthread (Coptis chinensis) is an early-diverging eudicot plant with diverse medicinal applications. The high-quality genome assembly and annotation of C. chinensis revealed a single ancient whole-genome duplication event shared by the Ranunculaceae family. The study also highlighted the functional importance of CYP719 gene in diversifying protoberberine-type alkaloids.

NATURE COMMUNICATIONS (2021)

Review Plant Sciences

Plant Metabolic Gene Clusters : Evolution, Organization, and Their Applications in Synthetic Biology

Revuru Bharadwaj et al.

Summary: Gene clusters responsible for specialized metabolites in plants offer a potential untapped source for highly useful biomolecules. These clusters evolve through gene duplications and neofunctionalization, tightly regulated at nucleosome level. Further research is needed to explore the significance and regulatory mechanisms of these gene clusters in plant biosynthesis.

FRONTIERS IN PLANT SCIENCE (2021)

Review Biochemistry & Molecular Biology

Ancestral sequence reconstruction - An underused approach to understand the evolution of gene function in plants?

Federico Scossa et al.

Summary: Ancestral proteins were more promiscuous than modern ones, with specificity often evolving after gene duplication; some modern proteins are found to have evolved de novo from ancestors lacking those functions; new interactions evolved from just a few mutations, suggesting acquisition of new functions is not difficult but often lost to subsequent mutations.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Article Plant Sciences

The Taxus genome provides insights into paclitaxel biosynthesis

Xingyao Xiong et al.

Summary: This study completed the chromosome-level genome sequencing of Taxus, revealing its genome evolution and the biosynthesis pathways of paclitaxel and taxadiene. A unique physical and functional grouping of CYP725As for paclitaxel biosynthesis was discovered in the Taxus genome, along with a gene cluster mainly formed by gene duplications for taxadiene biosynthesis.

NATURE PLANTS (2021)

Review Biochemistry & Molecular Biology

The scaffold-forming steps of plant alkaloid biosynthesis

Benjamin R. Lichman

Summary: Alkaloids from plants, known for their structural diversity and bioactivity, hold a privileged position in both modern and traditional medicines. Recent research has made significant progress in elucidating the biosynthetic origins of plant alkaloids. This review focuses on the metabolic origins of true alkaloids, specialized metabolites derived from amino acids with a nitrogen heterocycle, highlighting the key roles played by modifications to primary metabolism, iminium reactivity, and spontaneous reactions in the molecular and evolutionary origins of these pathways.

NATURAL PRODUCT REPORTS (2021)

Review Plant Sciences

Plant Metabolic Gene Clusters: Evolution, Organization, and Their Applications in Synthetic Biology

Revuru Bharadwaj et al.

Summary: Plants contain gene clusters encoding enzymes for the biosynthesis of specialized metabolites, which have evolved through gene duplications and neofunctionalization and are tightly regulated at nucleosome level. The prevalence of these gene clusters presents an attractive possibility of untapped source of highly useful biomolecules in plants.

FRONTIERS IN PLANT SCIENCE (2021)

Article Chemistry, Medicinal

Mining Natural Product Biosynthesis in Eukaryotic Algae

Ellis O'Neill

MARINE DRUGS (2020)

Article Multidisciplinary Sciences

Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy

Qiushi Li et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The evolution of metabolism: How to test evolutionary hypotheses at the genomic level

Federico Scossa et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Article Genetics & Heredity

Integrating transposable elements in the 3D genome

Alexandros Bousios et al.

MOBILE DNA (2020)

Article Multidisciplinary Sciences

Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants

Lingfeng Mao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

The evolutionary origins of the cat attractant nepetalactone in catnip

Benjamin R. Lichman et al.

SCIENCE ADVANCES (2020)

Editorial Material Plant Sciences

Doing the gene shuffle to close synteny: dynamic assembly of biosynthetic gene clusters

Reuben J. Peters

NEW PHYTOLOGIST (2020)

Review Plant Sciences

Gene and genome duplications in the evolution of chemodiversity: perspectives from studies of Lamiaceae

Benjamin R. Lichman et al.

CURRENT OPINION IN PLANT BIOLOGY (2020)

Editorial Material Multidisciplinary Sciences

Why are momilactones always associated with biosynthetic gene clusters in plants?

Juan Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Active and repressed biosynthetic gene clusters have distinct chromosome states

Hans-Wilhelm Nutzmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Formation and diversification of a paradigm biosynthetic gene cluster in plants

Zhenhua Liu et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Historical Meiotic Crossover Hotspots Fueled Patterns of Evolutionary Divergence in Rice

Alexandre P. Marand et al.

PLANT CELL (2019)

Review Plant Sciences

Evolution of Glucosinolate Diversity via Whole-Genome Duplications, Gene Rearrangements, and Substrate Promiscuity

Brenden Barco et al.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 70 (2019)

Article Multidisciplinary Sciences

A specialized metabolic network selectively modulates Arabidopsis root microbiota

Ancheng C. Huang et al.

SCIENCE (2019)

Review Plant Sciences

Roles of plant volatiles in defence against microbial pathogens and microbial exploitation of volatiles

Almuth Hammerbacher et al.

PLANT CELL AND ENVIRONMENT (2019)

Review Plant Sciences

Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity

Prema S. Karunanithi et al.

FRONTIERS IN PLANT SCIENCE (2019)

Article Biochemistry & Molecular Biology

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis

Benjamin R. Lichman et al.

NATURE CHEMICAL BIOLOGY (2019)

Review Plant Sciences

Why do plants produce so many terpenoid compounds?

Eran Pichersky et al.

NEW PHYTOLOGIST (2018)

Review Biochemistry & Molecular Biology

Metabolite-Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks

Lianet Noda-Garcia et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Review Biochemical Research Methods

Underground metabolism: network-level perspective and biotechnological potential

Richard A. Notebaart et al.

CURRENT OPINION IN BIOTECHNOLOGY (2018)

Article Multidisciplinary Sciences

Multigenome analysis implicates miniature inverted-repeat transposable elements (MITEs) in metabolic diversification in eudicots

Alexander M. Boutanaev et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Plant Sciences

The Sequenced Angiosperm Genomes and Genome Databases

Fei Chen et al.

FRONTIERS IN PLANT SCIENCE (2018)

Review Genetics & Heredity

Metabolic Gene Clusters in Eukaryotes

Hans-Wilhelm Nutzmann et al.

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

Article Multidisciplinary Sciences

The opium poppy genome and morphinan production

Li Guo et al.

SCIENCE (2018)

Review Genetics & Heredity

LTR-retrotransposons in plants: Engines of evolution

Leonardo Galindo-Gonzalez et al.

Review Plant Sciences

Tying the knot: occurrence and possible significance of gene fusions in plant metabolism and beyond

Jillian M. Hagel et al.

JOURNAL OF EXPERIMENTAL BOTANY (2017)

Article Biochemistry & Molecular Biology

The PhytoClust tool for metabolic gene clusters discovery in plant genomes

Nadine Topfer et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters

Satria A. Kautsar et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants

Jennifer H. Wisecaver et al.

PLANT CELL (2017)

Article Multidisciplinary Sciences

Blue fluorescent amino acid for biological spectroscopy and microscopy

Mary Rose Hilairea et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Echinochloa crus-galli genome analysis provides insight into its adaptation and invasiveness as a weed

Longbiao Guo et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Genome-wide analysis of chromatin packing in Arabidopsis thaliana at single-gene resolution

Chang Liu et al.

GENOME RESEARCH (2016)

Review Plant Sciences

Plant metabolic clusters - from genetics to genomics

Hans-Wilhelm Nutzmann et al.

NEW PHYTOLOGIST (2016)

Article Biochemistry & Molecular Biology

Delineation of metabolic gene clusters in plant genomes by chromatin signatures

Nan Yu et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Plant Sciences

Evolutionary trajectory of phytoalexin biosynthetic gene clusters in rice

Koji Miyamoto et al.

PLANT JOURNAL (2016)

Review Plant Sciences

Evolution of Gene Duplication in Plants

Nicholas Panchy et al.

PLANT PHYSIOLOGY (2016)

Article Multidisciplinary Sciences

Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism

Zhenhua Liu et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae

Jing Li et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

Scott C. Farrow et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Plant Sciences

Genome-guided investigation of plant natural product biosynthesis

Franziska Kellner et al.

PLANT JOURNAL (2015)

Article Multidisciplinary Sciences

The butterfly plant arms-race escalated by gene and genome duplications

Patrick P. Edger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

Thilo Winzer et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

Genome-wide analysis of local chromatin packing In Arabidopsis thaliana

Congmao Wang et al.

GENOME RESEARCH (2015)

Article Plant Sciences

Regulation of metabolic gene clusters in Arabidopsis thaliana

Hans-Wilhelm Nuetzmann et al.

NEW PHYTOLOGIST (2015)

Article Biochemistry & Molecular Biology

Acetylation serves as a protective group in noscapine biosynthesis in opium poppy

Thu-Thuy T. Dang et al.

NATURE CHEMICAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Investigation of terpene diversification across multiple sequenced plant genomes

Alexander M. Boutanaev et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Biochemical Research Methods

Gene clustering in plant specialized metabolism

Hans-Wilhelm Nuetzmann et al.

CURRENT OPINION IN BIOTECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

A Role for Volatiles in Intra- and Inter-Plant Interactions in Birch

P. Sarai Giron-Calva et al.

JOURNAL OF CHEMICAL ECOLOGY (2014)

Review Plant Sciences

The evolutionary paths towards complexity: a metabolic perspective

Jing-Ke Weng

NEW PHYTOLOGIST (2014)

Article Multidisciplinary Sciences

Biosynthesis, regulation, and domestication of bitterness in cucumber

Yi Shang et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

Tight Genetic Linkage of Prezygotic Barrier Loci Creates a Multifunctional Speciation Island in Petunia

Katrin Hermann et al.

CURRENT BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Evolution of a Complex Locus for Terpene Biosynthesis in Solanum

Yuki Matsuba et al.

PLANT CELL (2013)

Article Multidisciplinary Sciences

Genomic rearrangements and the evolution of clusters of locally adaptive loci

Sam Yeaman

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Characterization of CYP76M5-8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster

Qiang Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Multidisciplinary Sciences

The Rise of Chemodiversity in Plants

Jing-Ke Weng et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

Thilo Winzer et al.

SCIENCE (2012)

Review Plant Sciences

Why biosynthetic genes for chemical defense compounds cluster

Adam M. Takos et al.

TRENDS IN PLANT SCIENCE (2012)

Article Multidisciplinary Sciences

Formation of plant metabolic gene clusters within dynamic chromosomal regions

Ben Field et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Patching gaps in plant genomes results in gene movement and erosion of colinearity

Thomas Wicker et al.

GENOME RESEARCH (2010)

Article Genetics & Heredity

Transposed Genes in Arabidopsis Are Often Associated with Flanking Repeats

Margaret R. Woodhouse et al.

PLOS GENETICS (2010)

Review Plant Sciences

Protective perfumes: the role of vegetative volatiles in plant defense against herbivores

Sybille B. Unsicker et al.

CURRENT OPINION IN PLANT BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Benzoxazinoid biosynthesis, a model for evolution of secondary metabolic pathways in plants

Monika Frey et al.

PHYTOCHEMISTRY (2009)

Article Multidisciplinary Sciences

Evolution of a Novel Phenolic Pathway for Pollen Development

Michiyo Matsuno et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Identification of a biosynthetic gene cluster in rice for momilactones

Kazuhiro Shimura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice

K Otomo et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2004)

Review Plant Sciences

The formation and function of plant volatiles: perfumes for pollinator attraction and defense

E Pichersky et al.

CURRENT OPINION IN PLANT BIOLOGY (2002)