Journal
NUTRIENTS
Volume 14, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nu14081620
Keywords
doxorubicin; inflammation; oxidative stress; apoptosis; kidney injury; geraniol
Categories
Funding
- King Saud University, Riyadh, Saudi Arabia [RSP-2021/335]
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Pre-treatment with geraniol can alleviate doxorubicin-induced kidney damage in rats, improving kidney function, antioxidant parameters, and tissue structure. Geraniol also affects the expression of inflammatory and apoptosis-related genes and proteins, protecting the kidneys from doxorubicin-induced harm.
Doxorubicin-mediated kidney impairment is a serious problem in cancer treatment. Accordingly, this work investigated the ability of geraniol to modulate doxorubicin-induced kidney damage using a rat model. Rats were randomly assigned to four groups: control, doxorubicin (20 mg/kg, intraperitoneal, i.p.), doxorubicin plus 100 mg/kg of geraniol, and doxorubicin plus 200 mg/kg of geraniol. A single doxorubicin injection triggered kidney impairment, as evidenced by the altered serum creatinine, blood urea nitrogen, and albumin values; it also caused histological changes in the kidney architecture. Additionally, doxorubicin enhanced lipid peroxidation while lowering reduced glutathione, catalase activity, and the expression of glutathione peroxidase and superoxide dismutase. Interestingly, pre-treatment with geraniol rescued doxorubicin-induced alterations in kidney antioxidant parameters, enzymatic activity, and the expression of inflammatory and apoptosis-mediating gene and proteins. Moreover, prophylactic treatment with geraniol preserved most kidney histological characteristics in a dose-dependent manner. These findings support that geraniol could protect against doxorubicin-mediated kidney dysfunction. However, further research is needed to clarify the mechanisms of geraniol's protective effects against doxorubicin-mediated kidney dysfunction.
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