Journal
NATURE METABOLISM
Volume 4, Issue 5, Pages 505-506Publisher
NATURE PORTFOLIO
DOI: 10.1038/s42255-022-00563-3
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Funding
- European Research Council ERC (CGC: STG grant AstroNeuroCrosstalk) [757393]
- German Research Foundation DFG under Germany's Excellence Strategy [EXC 2145 SyNergy, 390857198]
- German Research Foundation DFG under Helmholtz Excellence Network
- Deutsche Forschungsgemeinschaft [GS: SPP1757 - SA2114/2-2]
- Helmholtz Association - Initiative and Networking Fund
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This study reveals that the BDNF-TrkB signalling pathway is not only regulated by neurons, but also by astrocytic TrkB.T1. Defective signalling of TrkB.T1 in hypothalamic circuits leads to obesity.
Until now, the BDNF-TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.
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