Journal
MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS
Volume 25, Issue -, Pages -Publisher
UNIV FED SAO CARLOS, DEPT ENGENHARIA MATERIALS
DOI: 10.1590/1980-5373-MR-2021-0534
Keywords
pectin; membrane; emulsion; carvacrol; antibacterial
Categories
Funding
- SEP-PRODEP [UNISON-PTC-331, 511-6/2020-B599]
- Division of Biological Science and Health of the University of Sonora [USO313006736]
- CONACyT
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In this study, a pectin membrane incorporated with a Tween-80-stabilized carvacrol emulsion was developed for wound dressing. The membrane showed good antibacterial activity against Escherichia coli and Staphylococcus aureus.
Interest in developing novel wound dressings with antibacterial properties elaborated from natural sources continues to grow. In this study, a Tween-80 (T80)-stabilized carvacrol (CAR) emulsion was incorporated into pectin (PEC) membranes at 0 (control), 0.25, 0.50, and 1.00% (v/v). Membranes were obtained by the dry-casting method, characterized by scanning electron microscopy, infrared spectroscopy, and CAR retention (HPLC), and tested for antibacterial activity. The retention percentage of CAR in the membranes ranged from 9.1-13.9%. Infrared spectra analysis indicated changes in the hydrogen bonds of the membranes that suggest an interaction between the polymer matrix and the CAR:T80 emulsion. Microstructural analysis of the membranes showed the presence of hole-like features on the surface (approximate to 4-6 mu m diameter) that indicate entrapment of the micelles in the matrix (microcapsules). The PEC-CAR membranes exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus, two pathogens commonly associated with wounds and intra-hospital infections.
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