Journal
ANNUAL REVIEW OF VISION SCIENCE, VOL 2
Volume 2, Issue -, Pages 17-35Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-vision-111815-114638
Keywords
visual cortex; retinogeniculate afferents; retinotectal system; circuit remodeling; structural plasticity; synapse dynamics
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Funding
- NEI NIH HHS [R01 EY025437, R01 EY017656, R01 EY011894] Funding Source: Medline
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During development, the environment exerts a profound influence on the wiring of brain circuits. Due to the limited resolution of studies in fixed tissue, this experience-dependent structural plasticity was once thought to be restricted to a specific developmental time window. The recent introduction of two-photon microscopy for in vivo imaging has opened the door to repeated monitoring of individual neurons and the study of structural plasticity mechanisms at a very fine scale. In this review, we focus on recent work showing that synaptic structural rearrangements are a key mechanism mediating neural circuit adaptation and behavioral plasticity in the adult brain. We examine this work in the context of classic studies in the visual systems of model organisms, which have laid much of the groundwork for our understanding of activity-dependent synaptic remodeling and its role in brain plasticity.
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