Journal
BIOMATERIALS SCIENCE
Volume 10, Issue 11, Pages 2907-2916Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2bm00374k
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Funding
- National Natural Science Foundation of China [21934002, 21804056]
- National First-class Discipline Program of Food Science and Technology [JUFSTR20180301]
- Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
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Bacterial infections pose a serious threat to public health, and finding a precise sterilization method is crucial. This study reports an intelligent theranostic platform that can be activated specifically by bacteria, combining photodynamic therapy and chemodynamic therapy to achieve precise sterilization and wound healing.
Bacterial infections pose a serious threat to public health. The integration of photodynamic therapy (PDT) and chemodynamic therapy (CDT) has emerged as a promising means to combat bacterial infection. However, most photosensitizers are often in the always on activated state and lack bacterial targeting, leading to non-specific damage to normal tissues. Besides, most of the conventional CDT systems are directly complexed with metal ions. The toxicity of excess free metal ions cannot be ignored. Therefore, it is a huge challenge to construct a bacteria-specific activated PDT/CDT synergistic therapy platform to achieve precise sterilization. Herein, we report a bacterial microenvironment-responsive phosphorescence/fluorescence dual-channel smart imaging-guided on-demand self-regulating CDT/PDT theranostic platform for precise sterilization and wound healing. Acid-degradable persistent luminescence nanoparticles were prepared as bacterial microenvironment-responsive phosphorescence imaging units and CDT agents. Piperazine-modified PEG was then introduced as an intelligent targeting and hydrophilic group, which was further bonded with a pH-reversibly-activated fluorescence/PDT-in-one probe to construct the intelligent theranostic platform. The developed platform combines the features of good biocompatibility, prolonged blood circulation, charge-reversed intelligent targetability, dual-channel smart imaging and on-demand self-regulating CDT/PDT effect, holding great potential for precise imaging-guided bacteria-specific synergistic sterilization without side effects.
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