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BIOPHYSICAL JOURNAL (2017)
Atypical Pneumonia Updates on Legionella, Chlamydophila, and Mycoplasma Pneumonia
Lokesh Sharma et al.
CLINICS IN CHEST MEDICINE (2017)
Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae
Mikhail Metelev et al.
ACS CHEMICAL BIOLOGY (2017)
Solving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis
Chengzhang Fu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection
William D. Chey et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)
A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis
Lauren Ray et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Lasso peptide, a highly stable structure and designable multifunctional backbone
Ning Zhao et al.
AMINO ACIDS (2016)
The bacterial enhancer-dependent RNA polymerase
Nan Zhang et al.
BIOCHEMICAL JOURNAL (2016)
Pseudouridine: the fifth RNA nucleotide with renewed interests
Xiaoyu Li et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2016)
Structure-activity relationship studies of new rifamycins containing L-amino acid esters as inhibitors of bacterial RNA polymerases
Dominika Czerwonka et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication
Yu Mi Lee et al.
GUT AND LIVER (2016)
Baseline abnormal liver function tests are more important than age in the development of isoniazid-induced hepatoxicity for patients receiving preventive therapy for latent tuberculosis infection
E. L. Gray et al.
INTERNAL MEDICINE JOURNAL (2016)
Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors
Walid A. M. Elgaher et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections
Zhenkun Ma et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Convergent Synthesis of the Dihydropyran Core Containing the C1-C15 Subunit of Sorangicin A Employing Gold(I)-Catalyzed Cyclization of an Allenic Alcohol
Sadagopan Raghavan et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B
Yu Feng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Development and Validation of a Risk Score for Clostridium difficile Infection in Medicare Beneficiaries: A Population-Based Cohort Study
Marya D. Zilberberg et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2016)
Bacterial Transcription as a Target for Antibacterial Drug Development
Cong Ma et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2016)
RNA Polymerase Pausing during Initial Transcription
Diego Duchi et al.
MOLECULAR CELL (2016)
The structure of tagetitoxin
Abil E. Aliev et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2016)
Regulation of transcriptional pausing through the secondary channel of RNA polymerase
Daria Esyunina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Ligand-induced and small-molecule control of substrate loading in a hexameric helicase
Michael R. Lawson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Structural basis of rifampin inactivation by rifampin phosphotransferase
Xiaofeng Qi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis
Xingwang Zhang et al.
TETRAHEDRON LETTERS (2016)
Rifamycins, Alone and in Combination
David M. Rothstein
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Tuberculosis
Madhukar Pai et al.
NATURE REVIEWS DISEASE PRIMERS (2016)
Mycobacterium bovis and Other Uncommon Members of the Mycobacterium tuberculosis Complex
Jaime Esteban et al.
MICROBIOLOGY SPECTRUM (2016)
Synthesis of Bridged Diketopiperazines by Using the Persistent Radical Effect and a Formal Synthesis of Bicyclomycin
Tynchtyk Amatov et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Advanced Mutasynthesis Studies on the Natural α-Pyrone Antibiotic Myxopyronin from Myxococcus fulvus
J. Henning Sahner et al.
CHEMBIOCHEM (2015)
Unified synthesis of tirandamycins and streptolydigins
Hikaru Yoshimura et al.
CHEMICAL COMMUNICATIONS (2015)
Treatment of Slowly Growing Mycobacteria
Julie V. Philley et al.
CLINICS IN CHEST MEDICINE (2015)
Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa
J. Henning Sahner et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Insights into Structure-Activity Relationships of Bacterial RNA Polymerase Inhibiting Corallopyronin Derivatives
Till F. Schaeberle et al.
JOURNAL OF NATURAL PRODUCTS (2015)
Identification of inhibitors of bacterial RNA polymerase
Xiao Yang et al.
METHODS (2015)
Structural basis of transcription initiation by RNA polymerase II
Sarah Sainsbury et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition
Brian Bae et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles
Yu Feng et al.
STRUCTURE (2015)
In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis
H. Sucipto et al.
CHEMICAL SCIENCE (2015)
Structure of a bacterial RNA polymerase holoenzyme open promoter complex
Brian Bae et al.
ELIFE (2015)
Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine- derived Streptomyces sp.
Hossam M. Hassan et al.
JOURNAL OF ANTIBIOTICS (2015)
New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
Nikolay Zenkin et al.
BIOMOLECULES (2015)
Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution
Mark S. Paget
BIOMOLECULES (2015)
Structural Biology of Bacterial RNA Polymerase
Katsuhiko S. Murakami
BIOMOLECULES (2015)
A Perspective on the Enhancer Dependent Bacterial RNA Polymerase
Nan Zhang et al.
BIOMOLECULES (2015)
Initial Events in Bacterial Transcription Initiation
Emily F. Ruff et al.
BIOMOLECULES (2015)
Diagnosis and Treatment of Extrapulmonary Tuberculosis
Ji Yeon Lee
TUBERCULOSIS AND RESPIRATORY DISEASES (2015)
Binding Mode Characterization of Novel RNA Polymerase Inhibitors Using a Combined Biochemical and NMR Approach
Martina Fruth et al.
ACS CHEMICAL BIOLOGY (2014)
Bacterial Sigma Factors: A Historical, Structural, and Genomic Perspective
Andrey Feklistov et al.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68 (2014)
Antibiotic Streptolydigin Requires Noncatalytic Mg2+ for Binding to RNA Polymerase
Savva Zorov et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent
Weixing Zhu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Common and unique features of viral RNA-dependent polymerases
Aartjan J. W. te Velthuis
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
Synthesis and Evaluation of Novel Analogues of Ripostatins
Wufeng Tang et al.
CHEMISTRY-A EUROPEAN JOURNAL (2014)
Medium optimization of Streptomyces sp 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J
Mostafa E. Rateb et al.
JOURNAL OF ANTIBIOTICS (2014)
Isolation and structure elucidation of the nucleoside antibiotic strepturidin from Streptomyces albus DSM 40763
Alexander Pesic et al.
JOURNAL OF ANTIBIOTICS (2014)
Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics
Muhammad Malik et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)
Interplay between the trigger loop and the F loop during RNA polymerase catalysis
Nataliya Miropolskaya et al.
NUCLEIC ACIDS RESEARCH (2014)
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria
Peter Spanogiannopoulos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
Anssi M. Malinen et al.
NATURE COMMUNICATIONS (2014)
Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity
Xuhua Mo et al.
RSC ADVANCES (2014)
Transcription inhibition by the depsipeptide antibiotic salinamide A
David Degen et al.
ELIFE (2014)
Fidaxomicin in Clostridium difficile infection: latest evidence and clinical guidance
Kathleen Mullane
THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2014)
Inhibitors of Bacterial Transcription Initiation Complex Formation
Cong Ma et al.
ACS CHEMICAL BIOLOGY (2013)
Archaeal transcription: making up for lost time
Magdalena N. Wojtas et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
Exploring Chemical Diversity of -Pyrone Antibiotics: Molecular Basis of Myxopyronin Biosynthesis
Hilda Sucipto et al.
CHEMBIOCHEM (2013)
Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America
Douglas R. Osmon et al.
CLINICAL INFECTIOUS DISEASES (2013)
Terminator still moving forward: expanding roles for Rho factor
Marc Boudvillain et al.
CURRENT OPINION IN MICROBIOLOGY (2013)
Fidaxomicin: A Review of Its Use in Patients with Clostridium difficile Infection
Lesley J. Scott
DRUGS (2013)
Novel small molecule inhibitors targeting the switch region of bacterial RNAP: Structure-based optimization of a virtual screening hit
J. Henning Sahner et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
Fidaxomicin inhibits toxin production in Clostridium difficile
Farah Babakhani et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2013)
X-ray Crystal Structure of Escherichia coli RNA Polymerase σ70 Holoenzyme
Katsuhiko S. Murakami
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Revised recommendations for the prevention of secondary Haemophilus influenzae type b (Hib) disease
Despoina Gkentzi et al.
JOURNAL OF INFECTION (2013)
Combining in Silico and Biophysical Methods for the Development of Pseudomonas aeruginosa Quorum Sensing Inhibitors: An Alternative Approach for Structure-Based Drug Design
J. Henning Sahner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
Vadim Molodtsov et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
An archaeal origin of eukaryotes supports only two primary domains of life
Tom A. Williams et al.
NATURE (2013)
Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes
Mario Altendorfer et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
Re-Annotation of Protein-Coding Genes in the Genome of Saccharomyces cerevisiae Based on Support Vector Machines
Dan Lin et al.
PLOS ONE (2013)
Fidaxomicin: A novel macrocyclic antibiotic for the treatment of Clostridium difficile infection
Tonya Crawford et al.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2012)
Total Synthesis of the Bacterial RNA Polymerase Inhibitor Ripostatin B
Florian Glaus et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Total Synthesis of RNA-Polymerase Inhibitor Ripostatin B and 15-Deoxyripostatin A
Wufeng Tang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
The Total Synthesis of Corallopyronin A and Myxopyronin B
Andreas Rentsch et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien
Mario Altendorfer et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Safety Analysis of Fidaxomicin in Comparison With Oral Vancomycin for Clostridium difficile Infections
Karl Weiss et al.
CLINICAL INFECTIOUS DISEASES (2012)
Fidaxomicin Inhibits Spore Production in Clostridium difficile
Farah Babakhani et al.
CLINICAL INFECTIOUS DISEASES (2012)
Antimicrobial Activities of Fidaxomicin
Ellie J. C. Goldstein et al.
CLINICAL INFECTIOUS DISEASES (2012)
Antimicrobial and Biofilm Inhibiting Diketopiperazines
M. P. de Carvalho et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Validation of PqsD as an Anti-biofilm Target in Pseudomonas aeruginosa by Development of Small-Molecule Inhibitors
Michael P. Storz et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Total Synthesis of (-)-Tirandamycin C
Ming Chen et al.
ORGANIC LETTERS (2012)
Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A
Avelina Espinosa et al.
PARASITOLOGY RESEARCH (2012)
Structural Basis of Transcription Initiation
Yu Zhang et al.
SCIENCE (2012)
Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp SCSIO1666
Xuhua Mo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Structural Basis for Promoter-10 Element Recognition by the Bacterial RNA Polymerase σ Subunit
Andrey Feklistov et al.
CELL (2011)
Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment
Francesca Tamarozzi et al.
CLINICAL MICROBIOLOGY REVIEWS (2011)
Archaeal RNA polymerase and transcription regulation
Sung-Hoon Jun et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2011)
New target for inhibition of bacterial RNA polymerase: 'switch region'
Aashish Srivastava et al.
CURRENT OPINION IN MICROBIOLOGY (2011)
The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea
Bedis Dridi et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate
Dina H. Horna et al.
JOURNAL OF BACTERIOLOGY (2011)
Amino Acid Precursor Supply in the Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin by Streptomyces lydicus
Cristina Gomez et al.
JOURNAL OF BACTERIOLOGY (2011)
Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop
Irina Artsimovitch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Chemical Synthesis Enables Biochemical and Antibacterial Evaluation of Streptolydigin Antibiotics
Sergey V. Pronin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Single-Molecule Studies of RNA Polymerase: One Singular Sensation, Every Little Step It Takes
Matthew H. Larson et al.
MOLECULAR CELL (2011)
Evolution of multisubunit RNA polymerases in the three domains of life
Finn Werner et al.
NATURE REVIEWS MICROBIOLOGY (2011)
Tirandamycins from Streptomyces sp 17944 Inhibiting the Parasite Brugia malayi Asparagine tRNA Synthetase
Zhiguo Yu et al.
ORGANIC LETTERS (2011)
Formal Synthesis of (+)-Sorangicin A
Michael T. Crimmins et al.
ORGANIC LETTERS (2011)
Characterization of TrdL as a 10-Hydroxy Dehydrogenase and Generation of New Analogues from a Tirandamycin Biosynthetic Pathway
Xuhua Mo et al.
ORGANIC LETTERS (2011)
(+)-Sorangicin A: evolution of a viable synthetic strategy
Amos B. Smith et al.
TETRAHEDRON (2011)
Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro
Sumandeep K. Gill et al.
TUBERCULOSIS (2011)
Translocation by multi-subunit RNA polymerases
Maria Kireeva et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2010)
The bridge helix coordinates movements of modules in RNA polymerase
Pyae P. Hein et al.
BMC BIOLOGY (2010)
Identification of the Tirandamycin Biosynthetic Gene Cluster from Streptomyces sp 307-9
Jacob C. Carlson et al.
CHEMBIOCHEM (2010)
Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS
Herbert Irschik et al.
CHEMBIOCHEM (2010)
Rifampin Combination Therapy for Nonmycobacterial Infections
Graeme N. Forrest et al.
CLINICAL MICROBIOLOGY REVIEWS (2010)
Stereoselective Total Synthesis of Etnangien and Etnangien Methyl Ester
Pengfei Li et al.
JOURNAL OF ORGANIC CHEMISTRY (2010)
Synthesis of Streptolydigin, a Potent Bacterial RNA Polymerase Inhibitor
Sergey V. Pronin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450
Micheal C. Wilson et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Origins and Evolution of Antibiotic Resistance
Julian Davies et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2010)
Molecular mechanisms of RNA polymerase-the F/E (RPB4/7) complex is required for high processivity in vitro
Angela Hirtreiter et al.
NUCLEIC ACIDS RESEARCH (2010)
Multiple roles of the RNA polymerase β' SW2 region in transcription initiation, promoter escape, and RNA elongation
Danil Pupov et al.
NUCLEIC ACIDS RESEARCH (2010)
A NusE:NusG Complex Links Transcription and Translation
Bjoern M. Burmann et al.
SCIENCE (2010)
The interaction between bacterial transcription factors and RNA polymerase during the transition from initiation to elongation
Xiao Yang et al.
TRANSCRIPTION-AUSTIN (2010)
RNA Polymerase Active Center: The Molecular Engine of Transcription
Evgeny Nudler
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives
Carlos Olano et al.
CHEMISTRY & BIOLOGY (2009)
Bacterial RNA Polymerase Inhibitors: An Organized Overview of their Structure, Derivatives, Biological Activity and Current Clinical Development Status
R. Mariani et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Neisseria meningitidis: epidemiology, treatment and prevention in adolescents
Kathryn S. Brigham et al.
CURRENT OPINION IN PEDIATRICS (2009)
Structures of RNA polymerase-antibiotic complexes
Mary X. Ho et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
Efflux-Mediated Drug Resistance in Bacteria An Update
Xian-Zhi Li et al.
DRUGS (2009)
The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA
Xiao Yang et al.
EMBO REPORTS (2009)
Salinisporamycin, a novel metabolite from Salinispora arenicora
Satoru Matsuda et al.
JOURNAL OF ANTIBIOTICS (2009)
Isolation and Characterization of Tirandamycins from a Marine-Derived Streptomyces sp.
Jacob C. Carlson et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Total Synthesis of Etnangien
Pengfei Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Total Synthesis of (+)-Sorangicin A
Amos B. Smith et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Allosteric control of catalysis by the F loop of RNA polymerase
Nataliya Miropolskaya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Rho directs widespread termination of intragenic and stable RNA transcription
Jason M. Peters et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The interaction of Bacillus subtilis σA with RNA polymerase
Elecia B. Johnston et al.
PROTEIN SCIENCE (2009)
Total synthesis of salinamide A: A potent anti-inflammatory bicyclic depsipeptide
Li Tan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
The RNA Polymerase Switch Region Is a Target for Inhibitors
Jayanta Mukhopadhyay et al.
CELL (2008)
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis
Mekonnen Kurabachew et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2008)
Stereochemical Determination and Complex Biosynthetic Assembly of Etnangien, a Highly Potent RNA Polymerase Inhibitor from the Myxobacterium Sorangium cellulosum
Dirk Menche et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264
Thomas A. Knappe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
The X-ray crystal structure of RNA polymerase from Archaea
Akira Hirata et al.
NATURE (2008)
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center
Andrey Feklistov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
Jennifer Baysarowich et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Structural evolution of multisubunit RNA polymerases
Finn Werner
TRENDS IN MICROBIOLOGY (2008)
RNA polymerase: the vehicle of transcription
Sergei Borukhov et al.
TRENDS IN MICROBIOLOGY (2008)
Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis:: a randomized placebo-controlled study
Achim Hoerauf et al.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2008)
In vitro activities of different inhibitors of bacterial transcription against Staphylococcus epidermidis biofilm
Philippe Villain-Guillot et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Structural basis for transcription elongation by bacterial RNA polymerase
Dmitry G. Vassylyev et al.
NATURE (2007)
Structural basis for substrate loading in bacterial RNA polymerase
Dmitry G. Vassylyev et al.
NATURE (2007)
Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli
Sophie Duquesne et al.
CHEMISTRY & BIOLOGY (2007)
Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases
Herbert Irschik et al.
JOURNAL OF NATURAL PRODUCTS (2007)
SorF:: A glycosyltransferase with promiscuous donor substrate specificity in vitro
Maren Kopp et al.
CHEMBIOCHEM (2007)
The RPB7 orthologue E′ is required for transcriptional activity of a reconstituted archaeal core enzyme at low temperatures and stimulates open complex formation
Souad Naji et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
David E. Griffith et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)
Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola
Philip G. Williams et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies
Simon Dawson et al.
NATURAL PRODUCT REPORTS (2007)
A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus
Francis Arhin et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Rifaximin: A novel nonabsorbed rifamycin for gastrointestinal disorders
JA Adachi et al.
CLINICAL INFECTIOUS DISEASES (2006)
Establishment of a real-time PCR protocol for expression studies of secondary metabolite biosynthetic gene clusters in the G/C-rich myxobacterium Sorangium cellulosum So ce56
C Kegler et al.
JOURNAL OF BIOTECHNOLOGY (2006)
Structural basis for transcription inhibition by tagetitoxin
DG Vassylyev et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Poorly absorbed antibiotics for the treatment of traveler's diarrhea
DN Taylor
CLINICAL INFECTIOUS DISEASES (2005)
Assembly of an RNA-protein complex -: Binding of NusB and NusE (S10) proteins to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli
SJ Greive et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Structural basis of transcription inhibition by antibiotic streptolydigin
D Temiakov et al.
MOLECULAR CELL (2005)
Inhibition of bacterial RNA polymerase by streptolydigin: Stabilization of a straight-bridge-helix active-center conformation
S Tuske et al.
CELL (2005)
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins
I Artsimovitch et al.
CELL (2005)
Cross-resistance of Escherichia coli RNA polymerases conferring rifarnpin resistance to different antibiotics
M Xu et al.
JOURNAL OF BACTERIOLOGY (2005)
The Wolbachia genome of Brugia malayi:: Endosymbiont evolution within a human pathogenic nematode
J Foster et al.
PLOS BIOLOGY (2005)
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
EA Campbell et al.
EMBO JOURNAL (2005)
A ratchet mechanism of transcription elongation and its control
G Bar-Nahum et al.
CELL (2005)
New inhibitors targeting bacterial RNA polymerase
SA Darst
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase I. Taxonomy, isolation and characterization
I Ciciliato et al.
JOURNAL OF ANTIBIOTICS (2004)
Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase
E Sarubbi et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)
Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS
H Kettenberger et al.
MOLECULAR CELL (2004)
Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation
T Doundoulakis et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel
J Mukhopadhyay et al.
MOLECULAR CELL (2004)
Microcin J25, from the macrocyclic to the lasso structure:: Implications for biosynthetic, evolutionary and biotechnological perspectives
S Rebuffat et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2004)
A new class of bacterial RNA polymerase inhibitor affects nucleotide addition
I Artsimovitch et al.
SCIENCE (2003)
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