4.5 Article

Embryonic Development in Relation to Maternal Obesity Does Not Affect Pregnancy Outcomes in FET Cycles

Journal

HEALTHCARE
Volume 10, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/healthcare10040703

Keywords

BMI; frozen embryo transfer; embryo morphokinetics; pregnancy rate

Ask authors/readers for more resources

This study examined the impact of maternal BMI on embryo morphokinetics and the outcomes of frozen embryo transfer cycles. The findings showed that embryos from normal-weight patients had slower cleavage rates compared to obese patients, but the quality of the embryos was similar between the BMI groups. There were no significant differences in pregnancy rate, clinical pregnancy rate, or miscarriage rate among the groups.
This retrospective cohort study examined the effect of maternal BMI on embryo morphokinetics using a time-lapse incubator (TLI) and evaluated the effect on outcomes of frozen embryo transfer (FET) cycles. The study included 641 women who underwent FET of a total of 2553 embryos from January 2017 to August 2019. The women were divided into four groups according to BMI: underweight (<18.5 kg/m(2)), normal weight (18.5-24.99 kg/m(2)), overweight (25.0-29.99 kg/m(2)), and obese (>= 30 kg/m(2)). Embryos were transferred on day 3 or 5, and their development was monitored using a TLI. We found that oocytes from obese patients were slower in the extraction of the second polar body (tPB2) after fertilization and the two pronucleus stage appeared later compared to normal-weight women. The time to fading of the pronucleus (tPNf), t2, and t4 were comparable between the four groups. Oocytes from underweight and overweight women had significantly faster cleavage at t3 and t5-t8 compared to normal weight. We did not find any significant difference in pregnancy rate, clinical pregnancy rate, or miscarriage rate among groups. In conclusion, embryos from normal-weight patients had slower cleavage rates compared to obese patients, while embryo quality was similar between BMI groups. The cycle outcomes demonstrated comparable pregnancy rates among the BMI groups.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available