Journal
RSC ADVANCES
Volume 12, Issue 21, Pages 12983-12987Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra02473j
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Funding
- National Natural Science Foundation of China [21901168]
- Sichuan Science and Technology Program [2021YJ0395]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
- 1000-Youth Talents Plan
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An efficient method for accessing gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis has been presented. This method offers mild reaction conditions, broad substrate scope, and good product yields. Additionally, gram-scale reactions have demonstrated the robustness and potential of this method. Control experiments have shown that the -CF3 group is essential for the success of this transformation. Finally, the practicality of this method has been successfully proven through three synthetic applications.
We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram-scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the -CF3 group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by three synthetic applications.
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