Journal
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
Volume 7, Issue 2, Pages -Publisher
VIETNAM NATL UNIV
DOI: 10.1016/j.jsamd.2022.100417
Keywords
Hybrid nanostructures; Silver-Titanium dioxide composites; Nanorods; Heterogeneous structure; Photodynamic therapy; Antimicrobial agent
Funding
- National Natural Science Foundation of China [81950410638]
- Key Research and Development Program of Zhejiang Province [2021C01180]
- Zhejiang International Science and Technology Cooperation Project [2019C04020]
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This work reports on the design of Ag decorated TiO2 hybrid nanorods with dual functionalities of enhanced photodynamic therapy and antibacterial activity. The Ag-TiO2 HNRs showed high intracellular ROS production in cancer cells under UV conditions, resulting in cancer cell apoptosis. They also exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus.
There has been significant interest in designing heterostructured nanoparticles with excellent synergistic properties and multifunctionality. Herein, this work reports on the design of reactive oxygen species(ROS-) responsive Ag decorated TiO2 hybrid nanorods (HNRs) with dual functionalities of enhanced photodynamic therapy and antibacterial activity. A de-wetting phenomenon was employed to nucleate and crystallize Ag nanoparticles onto the surface of TiO2 nanorods resulting in Ag-TiO2 hybrid nanocomposites. The use of the Pluronic (R) F-127 polymer, which is permitted by the Food and Drug Administration (FDA), remarkably improved the biocompatibility of Ag-TiO2 HNRs tested in 4T1 breast cancer cells. Furthermore, Ag-TiO2 HNRs endocytosed by cancer cells produced high intracellular ROS under UV conditions (5.6 mW cm(-2)), resulting in cancer cell apoptosis. Similarly, the distinctive features of Ag NPs on TiO2 nanorods slow down the recombination rate of electrons-holes, and exhibited 90% killing efficacy against Escherichia coli (gram-negative/rods) and Staphylococcus aureus (gram-positive/cocci). The potential of photo-activated Ag-TiO2 HNRs, as demonstrated in this work, indicates that this heterostructured material is a promising novel dual-therapeutic strategy against cancer cells and microbial agents. (C) 2022 Vietnam National University, Hanoi. Published by Elsevier B.V.
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