Study on the Allylation of Benzol[e][1,2,3]oxathiazine-2,2-dioxides

The allylation of benzol[e][1,2,3]oxathiazine-2,2-dioxides with allyl bromides promoted by tin powder was explored. The results showed that the allylation proceeded smoothly with high yields for a variety of substrates. When various allyl bromides were used to perform the reaction, the gamma-addition products were obtained. These allylated products underwent N-allylation reaction in the presence of base, and the diallylated products of benzol[e][1,2,3]oxathiazine-2,2-dioxides were obtained in high yields. The diallylated products of benzol[e][1,2,3] oxathiazine-2,2-dioxides further underwent ring closing metathesis reaction, and the cyclic derivatives of benzol[e][ 1,2,3] oxathiazine-2,2-dioxides were obtained in good yield.

Automated summary

The allylation of benzol[e][1,2,3]oxathiazine-2,2-dioxides with allyl bromides promoted by tin powder was investigated. The reaction proceeded smoothly with high yields for various substrates. The resulting allylated products underwent N-allylation reaction and then ring closing metathesis reaction, leading to the formation of diallylated products and cyclic derivatives of benzol[e][1,2,3]oxathiazine-2,2-dioxides, respectively.