Bronsted Acid-Catalyzed the Synthesis of Sulfoximide Substituted Dihydropyranone Derivatives

Both sulfoximide and dihvdropyranone derivatives have potential bioactivities. However, it is still undisclosed to prepare sulfoximide-substituted dihydropyranone derivatives. Herein, diphenyl phosphate, as Bronsted acid was used to catalyze the nucleophilic substitution reactions of sulfoximides and dihydropyranones to afford sulfoximide substituted dihvdropyranone derivatives in 44%similar to 78% yields. This method features mild conditions, simple operation and good functional group compatibility, which avoids using noble metals in traditional manners and provides a novel and effective strategy for the synthesis of glycosides.

Automated summary

In this study, diphenyl phosphate was used as a catalyst for the synthesis of sulfoximide-substituted dihydropyranone derivatives with yields ranging from 44% to 78%. The method features mild conditions and good functional group compatibility.