Journal
RSC ADVANCES
Volume 12, Issue 21, Pages 13087-13092Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra00331g
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Funding
- National Natural Science Foundation of China [81803374]
- Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine [BJRC2020002, BSH2019027]
- China Postdoctoral Science Foundation [2020M673565XB]
- Scienti.c Research Foundation of the Science & Technology Department of Sichuan Province [2018JY0599]
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A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction has been developed for the synthesis of multi-substituted pyrazoles using hydrazonoyl chlorides and cinnamic aldehydes. This protocol offers a broad substrate coverage, good functional group tolerance, wide scalability, operational simplicity, and convenient construction of pyrazole scaffolds.
A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions has been developed. A plausible stepwise cycloaddition reaction mechanism is proposed. This protocol featured broad substrate coverage, good functional group tolerance, wide scalability, and operational simplicity, as well as conveniently constructed pyrazole scaffolds.
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