Journal
BIO-DESIGN AND MANUFACTURING
Volume 5, Issue 3, Pages 451-464Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s42242-022-00190-7
Keywords
Functionally graded porous titanium scaffold; Tailored assembly system; Mechanical tunability; Multiple-biomolecule delivery; Bone tissue engineering
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2021R1I1A1A01043176, 2021R1A2C1091301, 2021K2A9A2A06037540]
- Korean Fund for Regenerative Medicine - Ministry of Science and ICT
- Ministry of Health and Welfare [2021M3E5E5096420]
- Korea government (the Ministry of Science and ICT)
- Ministry of Health & Welfare, Republic of Korea
- Ministry of Food and Drug Safety [202011B29]
- GRRC program of the Gyeo nggi Province [GRRC-KPU2021-A01]
- Multi-material Machining Innovative Technology Research Center
- National Research Foundation of Korea [2021K2A9A2A06037540, 2021R1A2C1091301, 2021R1I1A1A01043176] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, functionally graded porous Ti scaffolds were fabricated to overcome the issue of simultaneous release of multiple biomolecules. These scaffolds exhibited suitable mechanical properties, good structural stability, and prolonged release of specific biomolecules.
Porous titanium (Ti) scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical properties. However, naturally formed TiO2 on the surface limits fast osseointegration. Different biomolecules have been widely utilized to overcome this issue; however, homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release behaviors. In this study, functionally graded porous Ti scaffolds (FGPTs) with dense inner and porous outer parts were fabricated using a two-body combination and densification procedure. FGPTs with growth factor (BMP-2) and antibiotics (TCH) exhibited suitable mechanical properties as bone substituting material and presented good structural stability. The release of BMP-2 was considerably prolonged, whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds (control group). The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of BMP-2. The antimicrobial properties of these scaffolds were verified using S. aureus in terms of prior release time. In addition, various candidates for graded porous Ti scaffolds with altered pore characteristics were presented. [GRAPHICS] .
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