Journal
STEM CELL REVIEWS AND REPORTS
Volume 18, Issue 7, Pages 2351-2364Publisher
SPRINGER
DOI: 10.1007/s12015-022-10374-4
Keywords
Hematopoietic stem cells; Lineage positive cells; Stem cell purification; Cell cycle; Differentiation
Funding
- NIH/NHLBI [K08 HL118117]
- NIH/NIGMS, Pilot Project [1 P20 GM119943]
- Savit Foundation
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It has been demonstrated that hematopoietic stem cells alter the expression of differentiation markers B220 and Gr1 with cell cycle progression, indicating changes in their differentiation potential.
Hematopoietic stem cells express differentiation markers B220 and Gr1 and are proliferative. We have shown that the expression of these entities changes with cell cycle passage. Overall, we conclude that primitive hematopoietic stem cells alter their differentiation potential with cell cycle progression.
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