Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 2, Issue 12, Pages 2294-2303Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00497
Keywords
tannic acid; polymeric nanoparticles; surface functionalization; drug delivery
Categories
Funding
- NIH [R01 EB017791]
- Egyptian Government Ministry of Higher Education Missions Sector
- China Scholarship Council Fellowship
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1056997] Funding Source: National Science Foundation
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Polymeric nanoparticles (NPs) are decorated with various types of molecules to control their functions and interactions with specific cells. We previously used polydopamine (pD) to prime-coat poly(lactic-co-glycolic acid) (PLGA) NPs and conjugated functional ligands onto the NPs via the pD coating. In this study, we report tannic acid (TA) as an alternative prime coating that is functionally comparable to pD but does not have drawbacks of pD such as optical properties and interference of ligand characterization. TA forms a stable and optically inert coating on PLGA NPs, which can accommodate albumin, chitosan, and folate-terminated polyethylene glycol to control the cell-NP interactions. Moreover, TA coating allows for surface loading of polycyclic planar aromatic compounds. TA is a promising reactive intermediate for surface functionalization of polymeric NPs.
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