Plasma-Generated Poly(allyl alcohol) Antifouling Coatings for Cellular Attachment

Conformal poly(allyl alcohol) (PAA) coatings were grown on a biomedical grade polyurethane scaffold using pulsed plasma polymerization of the allyl alcohol monomer. The creation of a continuous wave polymer primer layer increases the interfacial adhesion and stability of a subsequent pulsed plasma deposited PAA film. The resulting PAA coatings are strongly hydrophilic and stable following 7 days incubation in biological media. Films prepared through this energy efficient, two-step process promote human dermal fibroblast cell culture, while resisting E. coli biofilm formation.