Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 86, Issue 6, Pages 775-779Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbac051
Keywords
Tschimganine; Mochimganine; chronological lifespan; fission yeast
Categories
Funding
- Japan Society for the Promotion of Science KAKENHI [JP19K15730, JP21K05363, JP21K14769, JP17H03792, JP 17K19227, JP20H02898]
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Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. However, its analog, Mochimganine, exhibits a significantly weaker growth inhibition effect while still being able to extend the lifespan.
Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition effect. Based on the comparative analysis of these compounds, we propose that Tschimganine has at least 2 targets: one extends the lifespan and the other inhibits growth.
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