Journal
CELL REPORTS MEDICINE
Volume 3, Issue 3, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.xcrm.2022.100562
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Funding
- NHMRC Leadership Investigator Grant [1173871]
- Center for Influenza Vaccine Research for High-Risk Populations (CIVR-HRP) [75N93019C00052, U01AI144616-02S1, R01AI136514]
- ALSAC at St. Jude
- National Health and Medical Research Council of Australia [1173871] Funding Source: NHMRC
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This article discusses epitope-specific CD8(+) and CD4(+) T cell responses to SARS-CoV-2 infection and vaccination, their persistence in long-term memory, and their role in limiting disease severity.
Robust T cell responses have been associated with milder outcomes in many infections. T cells also establish long-term memory pools and, as they are predominantly directed toward epitopes encompassing conserved peptides, can respond to SARS-CoV-2 variants, including Omicron. Here, we discuss epitope-specific CD8(+) and CD4(+) T cell responses toward SARS-CoV-2 infection and vaccination, their subsequent persistence into long-term memory, and ongoing work to determine their role in limiting disease severity.
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