Journal
ENVIRONMENTAL EPIDEMIOLOGY
Volume 6, Issue 1, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/EE9.0000000000000193
Keywords
External exposome; Immunome; Immune-mediated diseases; Multi-omics
Funding
- European Union [874707]
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This article introduces the EXIMIOUS consortium, a research project that aims to study the relationship between immune-mediated, noncommunicable diseases and environmental factors. By integrating large datasets and applying innovative bioinformatics tools, researchers will explore the immune system's response to exposome and identify early predictors of diseases.
Immune-mediated, noncommunicable diseases-such as autoimmune and inflammatory diseases-are chronic disorders, in which the interaction between environmental exposures and the immune system plays an important role. The prevalence and societal costs of these diseases are rising in the European Union. The EXIMIOUS consortium-gathering experts in immunology, toxicology, occupational health, clinical medicine, exposure science, epidemiology, bioinformatics, and sensor development-will study eleven European study populations, covering the entire lifespan, including prenatal life. Innovative ways of characterizing and quantifying the exposome will be combined with high-dimensional immunophenotyping and -profiling platforms to map the immune effects (immunome) induced by the exposome. We will use two main approaches that meet in the middle-one starting from the exposome, the other starting from health effects. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyze these large datasets to identify immune fingerprints that reflect a person's lifetime exposome or that are early predictors of disease. This will allow researchers, policymakers, and clinicians to grasp the impact of the exposome on the immune system at the level of individuals and populations.
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