Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 27, Issue 3, Pages -Publisher
IMR PRESS
DOI: 10.31083/j.fbl2703102
Keywords
coronavirus; cytokine storm; SARS; MERS; COVID-19; review
Categories
Ask authors/readers for more resources
There are currently seven known types of human coronaviruses (HCoVs), with low pathogenic and highly pathogenic categories. Low pathogenic HCoVs infect the upper respiratory tract, causing mild respiratory diseases. In contrast, highly pathogenic HCoVs infect the lower respiratory tract and cause fatal pneumonia, including diseases like SARS, MERS, and COVID-19. Understanding the role of cytokine storm in highly pathogenic HCoV infection is crucial.
At present, there are seven known types of human coronaviruses (HCoVs), which can be further divided into two categories: low pathogenic and highly pathogenic. The low pathogenic HCoVs infect the upper respiratory tract, mainly causing mild, cold-like respiratory diseases. By contrast, highly pathogenic HCoVs mainly infect the lower respiratory tract and cause fatal types of pneumonia, which include severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), as well as the recent outbreak of coronavirus disease 2019 (COVID-19). Highly pathogenic HCoV infection has a high morbidity and mortality, which is usually related to the strong immune response induced by highly proinflammatory cytokines, which is also known as cytokine storm. Therefore, it is particularly important to explore the role of cytokine storm in the process of highly pathogenic HCoV infection. We review the epidemiological and clinical manifestations of highly pathogenic HCoV infection, and reveal the pathology of cytokine storm and its role in the process of highly pathogenic HCoV infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available