4.6 Article

Enhanced enantioseparation of drugs by capillary electrochromatography with a l-cysteine functionalized gold nanoparticle based stationary phase

Journal

ANALYTICAL METHODS
Volume 14, Issue 20, Pages 1982-1987

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ay00414c

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Funding

  1. Project of the National Natural Science Foundation of China [82073809]

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The functionalized gold nanoparticle-based capillary column showed excellent chiral separation performance in separating drug enantiomers, with lactobionic acid as a chiral selector.
Nanoparticles, which have unique properties, have attracted growing attention in enantiomeric separation nowadays. In this paper, an l-cysteine functionalized gold nanoparticle (l-Cys-GNP) based capillary column was prepared and applied in separating drug enantiomers in capillary electrochromatography (CEC) with lactobionic acid (LA) as a chiral selector. Compared with bare fused-silica capillary columns, the capillary columns modified with l-Cys-GNPs showed excellent chiral separation performance. A series of parameters affecting the enantiomeric separation were systematically investigated.

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