Journal
FOOD CHEMISTRY: MOLECULAR SCIENCES
Volume 4, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fochms.2021.100063
Keywords
Aspergillus oryzae; Gut microbiome; Bifidobacterium pseudolongum; DSS-induced colitis; Prebiotics
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Funding
- Tojuro Iijima Foundation for Food Science and Technology [20K05815, 19K05802]
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Aspergillus oryzae can modulate the gut microbiota and alleviate colitis.
Aspergillus oryzae, a filamentous fungus, has long been used for the production of traditional Japanese foods. Here, we analyzed how A. oryzae administration affects the intestinal environment in mice. The results of 16S rRNA gene sequencing of the gut microbiota indicated that after the administration of heat-killed A. oryzae spores, the relative abundance of an anti-inflammatory Bifidobacterium pseudolongum strain became 2.0-fold greater than that of the control. Next, we examined the effect of A. oryzae spore administration on the development of colitis induced by dextran sodium sulfate in mice; we found that colitis was alleviated by not only heat-killed A. oryzae spores, but also the cell wall extracted from the spores. Our findings suggest that A. oryzae holds considerable potential for commercial application in the production of both traditional Japanese fermented foods and new foods with prebiotic functions.
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