4.6 Article

Active nanomotors surpass passive nanomedicines: current progress and challenges

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 10, Issue 37, Pages 7099-7107

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb00556e

Keywords

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Funding

  1. National Natural Science Foundation of China [52072095, 92163109]
  2. Shenzhen Science and Technology Program [JCYJ20200109113408066, KQTD20170809110344233]
  3. Fundamental Research Funds for the Central Universities [HIT.OCEF.2021032]
  4. GuangDong Basic and Applied Basic Research Foundation [2021A1515110272]
  5. Shenzhen Bay Laboratory [SZBL2019062801005]

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Artificial nanomotors have advantages over traditional nanomedicines in biomedical applications. This article summarizes recent developments of nanomotors in targeted drug delivery, biological barrier penetration, and diagnostics and cancer treatment. The challenges and potential solutions for the development of nanomotors in biomedical applications are discussed.
Artificial nanomotors show advantages over traditional nanomedicines in biomedical applications due to their active locomotion by converting various energy sources into mechanical force in situ. Currently, nanomotors are attracting wide attention in diagnosis and therapy towards clinical applications. In this perspective, we summarize recent developments of nanomotors in biomedical applications, including targeted drug delivery, biological barrier penetration, and diagnostics and cancer treatment. The development of nanomotors in biomedicine still faces considerable challenges and practical difficulties towards clinical use, which are discussed in detail. Finally, we propose potential solutions that may help the development of nanomotors towards advanced diagnostics and therapy.

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