Journal
CHEMICAL SCIENCE
Volume 13, Issue 21, Pages 6309-6315Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc01466a
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Funding
- New Energy and Industrial Technology Development Organisation (NEDO) [JPNP14004]
- Daiko Foundation [9226]
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An economical, solvent-free, and metal-free method for peptide synthesis via C-N bond cleavage using lactams has been developed, which exhibits high atom economy and can tolerate side chains bearing a range of functional groups, affording up to >99% yields of the corresponding peptides.
An economical, solvent-free, and metal-free method for peptide synthesis via C-N bond cleavage using lactams has been developed. The method not only eliminates the need for condensation agents and their auxiliaries, which are essential for conventional peptide synthesis, but also exhibits high atom economy. The reaction is versatile because it can tolerate side chains bearing a range of functional groups, affording up to >99% yields of the corresponding peptides without racemisation or polymerisation. Moreover, the developed strategy enables peptide segment coupling, providing access to a hexapeptide that occurs as a repeat sequence in spider silk proteins.
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