Cobalt-catalyzed tandem one-pot synthesis of polysubstituted imidazo[1,5-a]pyridines and imidazo[1,5-a]isoquinolines

An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1,5-a]-N-heteroaromatics. The method involves Knoevenagel condensation followed by cobalt-catalyzed direct alkenylation to give the desired polysubstituted imidazo[1,5-a]pyridines and imidazo[1,5-a]isoquinolines in a one-pot manner. This method exhibits a broad substrate scope, provides moderate to good (39-74%) yields and is amenable to scale-up to the gram scale.

Automated summary

An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1,5-a]-N-heteroaromatics, which involves Knoevenagel condensation followed by cobalt-catalyzed direct alkenylation. This method shows a broad substrate scope, moderate to good yields (39-74%), and scalability to gram scale.