Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2016.00127
Keywords
bone marrow stem cells; adipogenesis; secreted factors; bone marrow microenvironment; bone marrow stem cell subpopulations
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Funding
- Novo Nordisk Foundation [NNF15OC0016284]
- Interregional EU grant Bonebank [16-1.0-15]
- Inovationsfonden, Denmark
- OUH Research grant [15-A845]
- Novo Nordisk Foundation through the Danish Diabetes Academy
- Novo Nordisk Fonden [NNF15OC0016284] Funding Source: researchfish
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Bone marrow (BM) microenvironment represents an important compartment of bone that regulates bone homeostasis and the balance between bone formation and bone resorption depending on the physiological needs of the organism. Abnormalities of BM microenvironmental dynamics can lead to metabolic bone diseases. BM stromal cells (also known as skeletal or mesenchymal stem cells) [bone marrow stromal stem cell (BMSC)] are multipotent stem cells located within BM stroma and give rise to osteo-blasts and adipocytes. However, cellular and molecular mechanisms of BMSC lineage commitment to adipocytic lineage and regulation of BM adipocyte formation are not fully understood. In this review, we will discuss recent findings pertaining to identification and characterization of adipocyte progenitor cells in BM and the regulation of differentiation into mature adipocytes. We have also emphasized the clinical relevance of these findings.
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