Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 44, Pages 6453-6456Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc01503j
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Funding
- National Natural Science Foundation of China [NNSFC 21907075]
- Natural Science Foundation of Tianjin City [19JCZDJC32400, 18JCQNJC75900]
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An activatable mitochondria-targeted fluorescent probe Hcy-OPD was synthesized for the detection of methylglyoxal (MGO). The probe showed high selectivity and sensitivity for monitoring MGO (0.22 μM) and could be successfully applied in the imaging of exogenous and endogenous MGO in living cells.
An activatable mitochondria-targeted fluorescent probe Hcy-OPD was synthesized for the detection of methylglyoxal (MGO). For the introduction of a preorganized isopropylamino group on the aromatic o-diamine framework to regulate the hindrance effect, Hcy-OPD showed high selectivity and sensitivity (0.22 mu M) for monitoring MGO. The probe can be applied successfully in the imaging of exogenous and endogenous MGO in living cells.
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