Decarboxylative cyclization of o-chlorobenzoic acids with C,C-palladacycles formed by an aminopalladation/dealkylation strategy to access dibenzo[a,c]carbazoles

Herein a novel palladium-catalyzed tandem decarboxylative biscyclization of o-alkynylanilines with o-chlorobenzoic acids has been reported, which provides an efficient approach for the assembly of dibenzo[a,c]carbazoles. This protocol employs an intramolecular aminopalladation/dealkylation strategy to form C,C-palladacycles, which allow the construction of one C-N bond and two C-C bonds by reacting with o-chlorobenzoic acids. The method features a broad substrate scope and excellent functional group compatibility.

Automated summary

Herein, a new palladium-catalyzed reaction for the synthesis of dibenzo[a,c]carbazoles has been reported. This method utilizes an intramolecular aminopalladation/dealkylation strategy to form C,C-palladacycles, which can react with o-chlorobenzoic acids to construct one C-N bond and two C-C bonds. The method shows a broad substrate scope and excellent functional group compatibility.