Journal
FRONTIERS IN AGING NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.856628
Keywords
Alzheimer's Disease; biomarkers; microglia; microenvironment; PTAFR
Categories
Funding
- Key R&D Plan Guidance Project of Liaoning Province [2018225089]
- National Natural Science Foundation of China [81901309, 81603112]
- Doctoral Research Startup Fund Project of Liaoning Province [2019-BS-289]
- Key R&D Project of Liaoning Provincial Department of Science and Technology [ZF2019037]
- General Project of Liaoning Provincial Department of Science and Technology [2020-MS-161]
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Using bioinformatic analysis, we have identified PTAFR as a potential biomarker for early diagnosis and treatment of AD, which is associated with microglia-mediated microenvironment and can mediate inflammatory responses through the IL10-STAT3 pathway.
BackgroundEarly diagnosis and effective intervention are the keys to delaying the progression of Alzheimer's Disease (AD). Therefore, we aimed to identify new biomarkers for the early diagnosis of AD through bioinformatic analysis and elucidate the possible underlying mechanisms. Methods and ResultsGSE1297, GSE63063, and GSE110226 datasets from the GEO database were used to screen the highly differentially expressed genes. We identified a potential biomarker, Platelet activating factor receptor (PTAFR), significantly upregulated in the brain tissue, peripheral blood, and cerebrospinal fluid of AD patients. Furthermore, PTAFR levels in the plasma and brain tissues of APP/PS1 mice were significantly elevated. Simultaneously, PTAFR could mediate the inflammatory responses to exaggerate the microenvironment, particularly mediated by the microglia through the IL10-STAT3 pathway. In addition, PTAFR was a putative target of anti-AD compounds, including EGCG, donepezil, curcumin, memantine, and Huperzine A. ConclusionPTAFR was a potential biomarker for early AD diagnosis and treatment which correlated with the microglia-mediated microenvironment. It is an important putative target for the development of a novel strategy for clinical treatment and drug discovery for AD.
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