BF3-promoted reactions of α-amino acetals with alkynes to 2,5-disubstituted pyrroles

An efficient BF3-promoted cyclization of alpha-amino acetals with alkynes for the assembly of substituted pyrroles has been developed. This cascade process uses easily accessible alpha-amino acetals as raw materials and can be achieved under mild conditions through a simple metal-free operation.

Automated summary

An efficient BF3-promoted cyclization reaction has been developed for the synthesis of substituted pyrroles using easily accessible alpha-amino acetals as starting materials. This metal-free process can be carried out under mild conditions.