Endocrine disruptor chemicals, adipokines and reproductive functions

The prevalence of adult obesity has risen markedly in recent decades. The endocrine system precisely regulates energy balance, fat abundance and fat deposition. Interestingly, white adipose tissue is an endocrine gland producing adipokines, which regulate whole-body physiology, including energy balance and reproduction. Endocrine disruptor chemicals (EDCs) include natural substances or chemicals that affect the endocrine system by multiple mechanisms and increase the risk of adverse health outcomes. Numerous studies have associated exposure to EDCs with obesity, classifying them as obesogens by their ability to activate different mechanisms, including the differentiation of adipocytes, increasing the storage of triglycerides, or elevating the number of adipocytes. Moreover, in recent years, not only industrial deception and obesity have intensified but also the problem of human infertility. Reproductive functions depend on hormone interactions, the balance of which may be disrupted by various EDCs or obesity. This review gives a brief summary of common EDCs linked with obesity, the mechanisms of their action, and the effect on adipokine levels, reproduction and connected disorders, such as polycystic ovarian syndrome, decrease in sperm motility, preeclampsia, intrauterine growth restriction in females and decrease of sperm motility in males.

Automated summary

The prevalence of adult obesity has increased significantly, and the endocrine system plays a crucial role in energy balance and fat deposition. Endocrine disruptor chemicals (EDCs) have been extensively studied for their association with obesity. EDCs can trigger obesity through various mechanisms, such as influencing adipocyte differentiation, increasing triglyceride storage, or elevating adipocyte number. Furthermore, EDCs and obesity may affect reproductive functions and lead to conditions like polycystic ovarian syndrome and decreased sperm motility.