Journal
ACS APPLIED BIO MATERIALS
Volume 5, Issue 4, Pages 1794-1803Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.2c00150
Keywords
copper-selenocysteine QDs; Cu+-based nanocatalyzer; chemodynamic therapy; Fenton-like reaction; near-infrared-II irradiation
Funding
- National Natural Science Foundation of China [21734006]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21821001]
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Researchers have developed copper-selenocysteine quantum dots (Cu-Sec QDs) using a facile and robust thermal titration process. These QDs exhibit strong photothermal enhancement of Fenton-like reaction and cytotoxicity, showing great potential for cancer treatment.
Chemodynamic therapy has been appealing for effective cancer treatment. Particularly, Fenton-like reactions catalyzed by Cu2+-based nanoparticles showed promising prospects. Herein, we fabricated copper-selenocysteine quantum dots (Cu-Sec QDs) with the majority of Cu+ by a facile and robust thermal titration process. No high temperature or pressure is needed for this synthetic route of QDs. The selenocysteine functioned as the reducing agent as well as the stabilizer, circumventing the poor water solubility and stability, leading to enhanced biocompatibility. The existence of Cu+ endowed the QDs the ability to catalyze the Fenton-like reaction without an extra reduction reaction of Cu2+ to Cu+. Moreover, the strong absorption in the near-infrared-II region (1000-1300 nm) of the final Cu-Sec QDs is in great favor of the chemodynamic therapy via the photothermally enhanced Fenton-like reaction. And the Cu-Sec QDs exhibited obvious cytotoxicity to various cancer cell lines. We believe that this facile and robust synthetic approach could open up another method for the fabrication of quantum dots toward the potential Fenton-like based applications in biological fields.
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