Journal
JOURNAL OF CANCER
Volume 13, Issue 7, Pages 2430-2439Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.71619
Keywords
Lysophosphatidylcholine acyltransferase 3; Phosphatidylcholine; Atherosclerosis; Inflammation; Nonalcoholic steatohepatitis; Cancer
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Funding
- National Nature Science Foundation of China [82104466]
- Shanghai Frontier Research Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation [2021KJ03-12]
- Shanghai Rising-Star Program [20QA1409300]
- Program for Young Eastern Scholar at Shanghai Institutions of Higher Learning [QD2019034]
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This review summarizes the important role and mechanism of lysophosphatidylcholine acyltransferase 3 (LPCAT3) in various diseases, and aims to provide new ideas for the treatment of these diseases.
Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasis. Lysophosphatidylcholine acyltransferase 3 (LPCAT3, MBOAT5) is a member of the LPCAT family that primarily regulates the levels of arachidonic PC species. LPCAT3 is regulated by the liver X receptor, which plays an important role in lipoprotein production in the liver and small intestine. Increasing lines of research have demonstrated that LPCAT3 plays important roles in the occurrence and development of many diseases, such as atherosclerosis, intestinal tumors, and nonalcoholic steatohepatitis (NASH). The development of many diseases has been linked to the proinflammatory effects of LPCAT3. This review focuses on the current knowledge of LPCAT3, including its function and mechanism in different diseases. We aim to provide a comprehensive and in-depth understanding of LPCAT3 and to provide new ideas for the treatment of some diseases.
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