Journal
SCIENCE CHINA-MATERIALS
Volume 59, Issue 4, Pages 254-264Publisher
SCIENCE PRESS
DOI: 10.1007/s40843-016-5035-6
Keywords
drug delivery; copper chalcogenide; atom transfer radical polymerization; near infrared light; chcmo/photothermo-therapy
Categories
Funding
- National Natural Science Foundation of China [21475007, 21275015, 21505003]
- Fundamental Research Funds for the Central Universities [YS1406, buctrc201507, buctrc201608]
- Beijing University of Chemical Technology
- High-Level Faculty Program of Beijing University of Chemical Technology [buctrc201325]
- BUCT Fund for Disciplines Construction and Development [XK1526]
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Drug delivery systems (DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment efficacy and reducing side effects faces great challenge. We report a kind of smart nanocomposites (NCs) that is sensitive to the surrounding temperature by grafting a layer of thermosensitive polymer, poly(N-isopropylacrylamide) (pNIPAm), on the surface of single Cu7S4 nanoparticle (NP) via atom transfer radical polymerization (ATRP). These NCs demonstrate a photothermal conversion efficiency of 25.4% under 808-nm near infrared (NIR) light irradiation and a drug loading content of 19.4% (drug/total NCs, w/w) with a lower critical solution temperature (LCST) of similar to 38 degrees C. At normal physiological temperature (37 degrees C), only 10.8% of the loaded doxorubicin (DOX) was released at physiological pH value (pH 7.4) within 10 h. In the presence of 808-nm irradiation, due to the temperature increment as a result of photothermal effects, DOX was rapidly released.
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