Journal
BIOMATERIALS SCIENCE
Volume 10, Issue 13, Pages 3371-3392Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2bm00179a
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Funding
- Direktorat Jenderal Pendidikan Tinggi (DIKTI) of the Indonesia Ministry of Education
- Australian Research Council [IH150100024]
- Australian Research Council [IH150100024] Funding Source: Australian Research Council
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Pelvic organ prolapse occurs when the weakening of pelvic floor muscles and tissue leads to the herniation of surrounding organs into the vagina and/or rectum. Permanent meshes, while effective, have high complication rates and are banned in many countries. There is a need for a new material that can provide tissue support without complications.
Pelvic organ prolapse is the herniation of surrounding tissue and organs into the vagina and/or rectum and is a result of the weakening of pelvic floor muscles, connective tissue, and fascia. It is widely accepted that 50% of women will develop prolapse, with the prevalence increasing with age, and up to 10-20% of those seek evaluation for their condition. Suture repairs of pelvic floor defects are associated with a high failure rate, and permanent meshes were introduced to reduce the recurrence rate. The meshes were successful in reducing the rate of recurrence but were also associated with a higher rate of complications (pain or erosion into surrounding organs) and as such have been banned in many countries. New materials that are able to provide tissue support without complications are urgently required. A promising new material may be a biodegradable metal, which provides support during healing and subsequently completely degrades. We summarise pelvic mesh usage, and evaluate the use of a biodegradable metal, which has advantages of biocompatibility, antibacterial properties, and mechanical properties. The remaining challenges are discussed as follows: (1) degradation rate, (2) stiffness, (3) corrosion fatigue, (4) zinc aging, and (5) MRI artifacts.
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