Journal
TOPICS IN CURRENT CHEMISTRY
Volume 374, Issue 2, Pages -Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s41061-016-0012-8
Keywords
Hydrogen transfer; Alkylation; Alcohol; Metal halide; Methanol; Guerbet reaction
Categories
Ask authors/readers for more resources
The development of practical, efficient, and atom-economical methods for the formation of carbon-carbon bonds remains a topic of considerable interest in current synthetic organic chemistry. In this review, we have summarized selected topics from the recent literature with particular emphasis on C-alkylation processes involving hydrogen transfer using alcohols as alkylation reagents. This review includes selected highlights concerning recent progress towards the modification of catalytic systems for the alpha-alkylation of ketones, nitriles, and esters. Furthermore, we have devoted a significant portion of this review to the methylation of ketones, alcohols, and indoles using methanol. Lastly, we have also documented recent advances in beta-alkylation methods involving the dimerization of alcohols (Guerbet reaction), as well as new developments in C-alkylation methods based on sp 3 C-H activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available