Journal
MATERIALS & DESIGN
Volume 92, Issue -, Pages 674-681Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2015.12.043
Keywords
Poly(vinylidene fluoride); Scaffolds; Tissue engineering; Mechanical properties; Piezoelectric
Categories
Funding
- FEDER funds through the Programa Operacional Fatores de Competitividade - COMPETE
- FCT Fundacao para a Ciencia e a Tecnologia [PEST-C/FIS/U1607/2014, SFRH/BD/82411/2011, SFRH/BPD/90870/2012]
- COST Action [MP1301]
- Ministerio de Economia y Competitividad, MINECO [MAT2013-46467-C4-1-R]
- VI National RDi Plan
- Iniciativa Ingenio
- Consolider Program
- CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
- Fundação para a Ciência e a Tecnologia [SFRH/BD/82411/2011, NANO/NMed-SD/0156/2007, PTDC/CTM-NAN/112574/2009] Funding Source: FCT
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Cell supports based on electroactive materials, that generate electrical signal variations as a response to mechanical deformations and vice-versa, are gaining increasing attention for tissue engineering applications. In particular, poly(vinylidene fluoride), PVDF, has been proven to be suitable for these applications in the form of films and two-dimensional membranes. In this work, several strategies have been implemented in order to develop PVDF three-dimensional scaffolds. Three processing methods, including solvent casting with particulate leaching and three-dimensional nylon, and freeze extraction with poly(vinyl alcohol) templates are presented in order to obtain three-dimensional scaffolds with different architectures and interconnected porosity. Further, it is shown that the scaffolds are in the electroactive beta-phase and show a crystallinity degree of similar to 45%. Finally, quasi-static mechanical measurements showed that an increase of the porous size within the scaffold leads to a tensile strengths and the Young's modulus decrease, allowing tuning scaffold properties for specific tissues. (C) 2015 Elsevier Ltd. All rights reserved.
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