Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 63, Issue 5, Pages 649-658Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.121.263506
Keywords
cardiology (basic/technical); cardiology (clinical); molecular imaging; inflammation; myocardial perfusion imaging
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The development of new radiotracers is crucial in cardiovascular medicine to address unmet diagnostic needs and support personalized therapies. This review discusses emerging radiotracers for cardiovascular imaging, covering perfusion, neuronal imaging, inflammation, fibrosis, thrombosis, calcification, and cardiac amyloidosis.
The development of new radiotracers for PET and SPECT is central to addressing unmet diagnostic needs related to systemwide trends toward molecular characterization and personalized therapies in cardiovascular medicine. In the following 2-part review, we discuss select emerging radiotracers that may help address important unmet diagnostic needs in central areas of cardiovascular medicine, such as heart failure, arrhythmias, valvular disease, atherosclerosis, and thrombosis. Part 1 examines key technical considerations pertaining to cardiovascular radiotracer development and reviews emerging radiotracers for perfusion and neuronal imaging. Highlights of this work include discussions on the development of F-18-flurpiridaz, an emerging PET perfusion tracer, and the development of F-18-based radiotracers for cardiovascular neuronal imaging, such as F-18-flubrobenguane. Part 2 of this review covers emerging radiotracers for the imaging of inflammation, fibrosis, thrombosis, calcification, and cardiac amyloidosis.
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