Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 +/- 6 nm and 12 +/- 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.

Automated summary

This study investigated the anti-inflammatory and anti-nociceptive effects of nanoemulsion-based gels containing cinnamon and clove essential oils in an animal model. The results showed significant effects in inhibiting inflammation and pain. These nanogels can be considered as analgesic drugs for treating inflammatory and painful conditions.