4.6 Review

Pyridine: the scaffolds with significant clinical diversity

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines

Chekuri Sharmila Rani et al.

Summary: A novel series of amide functionalized imidazo[1,2-a]pyridine derivatives were synthesized and screened for their anticancer activities, among which compound 14j showed the highest potency against multiple cancer cell lines.

MEDICINAL CHEMISTRY RESEARCH (2021)

Article Chemistry, Physical

Novel 2,6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis

Sevil Senkardes et al.

Summary: Novel pyridine-based dihydrazones showed limited antibacterial activity, but exhibited significant anticancer activity against human colon cancer cell and human endometrial cancer cell lines, with low toxicity.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Chemistry, Medicinal

Antiviral Activities of Pyridine Fused and Pyridine Containing Heterocy-cles, A Review (from 2000 to 2020)

Seyedeh Roya Alizadeh et al.

Summary: Pyridine, as a six-membered heterocyclic compound, plays a critical role in medicinal chemistry with various biological activities. Pyridine derivatives are classified into two categories, including pyridine containing heterocycles and pyridine fused rings. Studies have shown that these derivatives exhibit good antiviral activity against different types of viruses with various action mechanisms. Further investigations in vivo and clinical testing are needed for better evaluations in the future.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Yong Ling et al.

Summary: Pyridine-based ring systems are extensively used in drug design, with many therapeutic agents derived from pyridine or dihydropyridine approved for various diseases. The prospects of more drugs containing these two heterocycles in the future look promising, as they continue to play an expanding role in medicinal chemistry and drug development.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Chemistry, Multidisciplinary

Pyridine-Conjugated Pillar[5]arene: From Molecular Crystals of Blue Luminescence to Red-Emissive Coordination Nanocrystals

Xin-Yue Lou et al.

Summary: By employing a facile supramolecular self-assembling strategy, a luminescent molecular crystal and a Cu(I)-coordinated luminescent nanocrystal were simultaneously prepared using a conjugated pillar[5]arene macrocycle. The molecular crystal exhibited enhanced luminescence due to its conjugated structure and staggered packing mode, while the coordination nanocrystal showed well-defined crystalline structures and long-lifetime triplet state emission with distinct solvochromic features.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Pharmacology & Pharmacy

Recent Development in Nuclear Magnetic Resonance as a Technique for Quantitative Method Validation

R. Sahu et al.

Summary: Nuclear magnetic resonance spectroscopy has been widely used for the routine analysis of natural, synthetic drug candidates, and related molecules. This review focuses on the feasibility and effectiveness of using nuclear magnetic resonance for quantitative method validation of drugs and related compounds, showing that it is a reliable alternative to chromatography-based techniques for quantitative analysis.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Chemistry, Medicinal

One-pot Synthesis of Betulin Triterpenoid Quaternized Pyridine Derivatives and their Antimicrobial Activity

Elvira Rifovna Shakurova et al.

LETTERS IN DRUG DESIGN & DISCOVERY (2020)

Article Chemistry, Multidisciplinary

Synthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties

Zhiwei Chen et al.

ARABIAN JOURNAL OF CHEMISTRY (2019)

Article Chemistry, Medicinal

Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids

Hong Dai et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability

Mohamed A. Abdelgawad et al.

BIOORGANIC CHEMISTRY (2018)

Article Chemistry, Medicinal

Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors

P. V. Sri Ramya et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Mohamed El-Naggar et al.

MOLECULES (2018)

Article Chemistry, Multidisciplinary

Design, synthesis and in vitro -glucosidase inhibition of novel coumarin-pyridines as potent antidiabetic agents

Mehdi Adib et al.

NEW JOURNAL OF CHEMISTRY (2018)

Review Chemistry, Medicinal

Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents

Aakash Deep et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Synthesis and in vitro evaluation of dihydro-6H-chromeno[4,3-b]isoxazolo[4,5-e]pyridine derivatives as potent antidiabetic agents

Lingala Suresh et al.

RESEARCH ON CHEMICAL INTERMEDIATES (2017)

Article Chemistry, Multidisciplinary

A Series of Pyridines and Pyridine Based Sulfa-Drugs as Antimicrobial Agents: Design, Synthesis and Antimicrobial Activity

H. A. El-Sayed et al.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Synthesis and antitubercular evaluation of imidazo[2,1-b][1,3,4]thiadiazole derivatives

Harun M. Patel et al.

ARABIAN JOURNAL OF CHEMISTRY (2017)

Article Chemistry, Medicinal

Synthesis of new diarylamides with pyrimidinyl pyridine scaffold and evaluation of their anti-proliferative effect on cancer cell lines

Ahmed Z. Abdelazem et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Chemistry, Organic

SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL MULTISUBSTITUTED 6,7-DIHYDRO-5HCYCLOPENTA[ b] PYRIDINE DERIVATIVES

Meliha Burcu Gurdere et al.

SYNTHETIC COMMUNICATIONS (2014)

Article Chemistry, Medicinal

Antioxidant, cytotoxicity, and QSAR study of 1-adamantylthio derivatives of 3-picoline and phenylpyridines

Apilak Worachartcheewan et al.

MEDICINAL CHEMISTRY RESEARCH (2012)

Article Chemistry, Multidisciplinary

Inverse Electron Demand Diels-Alder Reactions of 1,2,3-Triazines: Pronounced Substituent Effects on Reactivity and Cycloaddition Scope

Erin D. Anderson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Chemistry, Medicinal

Synthesis and evaluation of a series of aminocyanopyridines as antimicrobial agents

Aliye Altundas et al.

MEDICINAL CHEMISTRY RESEARCH (2011)

Article Chemistry, Medicinal

Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

Jean-Michel Chezal et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Chemistry, Medicinal

Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives

Ahmet Ozdemir et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk-3-en-2-ones

Abdolmajid Riahi et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Synthesis, Spectral and Microbial Studies of Some Novel Schiff Base Derivatives of 4-Methylpyridin-2-amine

J. J. Vora et al.

E-JOURNAL OF CHEMISTRY (2009)

Article Chemistry, Medicinal

Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities

Thummaruk Suksrichavalit et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

Synthesis and reactions of 3-acetyl-6-methyl-2-(methylthio)pyridine

V. K. Zav'yalova et al.

RUSSIAN CHEMICAL BULLETIN (2009)

Article Chemistry, Medicinal

Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities

Jong-Keun Son et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Synthesis, antibacterial and antifungal activities of 3-aryl-5-(pyridin-3-y1)-4,5-dihydropyrazole-1-carbothioamide derivatives

M. Shekarchi et al.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2008)

Article Chemistry, Medicinal

Synthesis and antimalarial evaluation of novel pyridine quinoline hybrids

Badri Narayan Acharya et al.

MEDICINAL CHEMISTRY RESEARCH (2008)

Article Chemistry, Inorganic & Nuclear

Microwave assisted synthesis of some pyridine derivatives containing mercaptotriazole and thiazolidinone as a new class of antimicrobial agents

Sarika Mehta et al.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2008)

Article Biochemistry & Molecular Biology

Synthesis and antidiabetic activity of 2,5-disubstituted-3-imidazol-2-yl-pyrrolo[2,3-b]pyridines and thieno[2,3-b]pyridines

Rajesh H. Bahekar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis and antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines

Gabriel Navarrete-Vazquez et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives

Maria T. Cocco et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110 alpha inhibitors

Masahiko Hayakawa et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series

Luiza R. S. Dias et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives

Alice Maria Rolim Bernardino et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives

Sham M. Sondhi et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Chemistry, Medicinal

Synthesis and antimicrobial activity of 5-hydroxymethyl-8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides

IO Zhuravel' et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Chemistry, Medicinal

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione

BY Kim et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2004)

Article Chemistry, Organic

De novo synthesis of substituted pyridines

GD Henry

TETRAHEDRON (2004)

Article Biochemistry & Molecular Biology

In vitro antitumor activities of 2,6-di-[2-(Heteroaryl)vinyllpyridines and pyridiniums

V Barresi et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Chemical synthesis and biological properties of pyridine epothilones

KC Nicolaou et al.

CHEMISTRY & BIOLOGY (2000)