Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 13, Pages 3467-3472Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00164k
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Funding
- National Natural Science Foundation of China [21971103]
- Shenzhen Science and Technology Innovation Commission [JCYJ20200109141408054]
- Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
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In this study, the first rhodium(I)-catalyzed asymmetric carbene insertion approach for C-S bond formation was developed using a chiral diene as a ligand. This method allows the synthesis of a range of potentially valuable alpha-thioesters in high yields with moderate to good enantioselectivities under mild conditions.
Asymmetric construction of C-S bonds through transition-metal catalysis is a challenging subject. By using chiral diene as the ligand, we have developed the first rhodium(i)-catalyzed asymmetric carbene insertion approach for C-S bond formation to access sulfur-substituted stereocenters under mild conditions, allowing the facile synthesis of a range of potentially valuable alpha-thioesters in high yields with moderate to good enantioselectivities.
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