Journal
DALTON TRANSACTIONS
Volume 51, Issue 21, Pages 8258-8265Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt00571a
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Funding
- SERB-DST, Govt of India [CRG/2019/006038]
- IISER Bhopal
- UGC
- SERB
- DST
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In this study, water-soluble Ru-NHC complexes were synthesized and tested for their catalytic activity in the transfer hydrogenation of quinoline-type N-heteroarenes using a formic acid/sodium formate buffer solution. The designed ligand within the catalyst backbone exhibited excellent durability, reusability, and compatibility with aqueous-phase operation. The catalytic system demonstrated high efficiency with as little as 0.25 mol% catalyst, providing an overall turnover number of approximately 900.
Water-soluble Ru-NHC complexes were synthesized and their catalytic activity was tested in the transfer hydrogenation of quinoline-type N-heteroarenes using a formic acid/sodium formate buffer solution. The unique multifunctional features of the designed ligand within the catalyst backbone endowed it with excellent durability, reusability and compatibility with a simple aqueous-phase operation. Thus, it was possible to reuse as little as 0.25 mol% of the catalyst for three consecutive catalytic runs to provide an overall turnover number of around 900. A mechanistic investigation suggested that hydride generation was the rate-limiting step, whereas hydride transfer was relatively facile. Furthermore, computational studies supported that the reaction pathway was dominated by 1,4-hydride insertion at the N-heteroarene substrates.
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