Journal
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
Volume 36, Issue 1, Pages 35-41Publisher
BIOLIFE SAS
Keywords
oxidative stress; ROS; antioxidant; alpha-lipoic acid; acetyl l-carnitine; ototoxicity; tinnitus; hypoacusis; trigeminal neuralgia; burning mouth syndrome
Ask authors/readers for more resources
During physiological processes and stressful conditions, the release of free radicals can lead to oxidative stress, damaging the structure and functionality of proteins, lipids, and nucleic acids. Mitochondria are highly impacted by oxidative stress, causing mitochondrial dysfunction and tissue damage. Oxidative stress is involved in the development of various pathological processes, and antioxidant molecules can inhibit the production of free radicals and the perpetuation of inflammation.
During physiological processes and stressful conditions (pollution, chemical agents, radiation, sports), the body releases free radicals, especially reactive oxygen species (ROS), unstable and particularly reactive molecules. Although the body has developed several defence mechanisms to neutralise free radicals, ROS production can increase in numerous conditions, triggering an imbalance redox condition known as oxidative stress, which affects proteins, lipids and nucleic acids, damaging their structure and their normal functionality. Mitochondria are the major producers of ROS and organelles that undergo the most impacting structural and functional alterations in case of oxidative stress. Mitochondrial dysfunctions caused by ROS accumulation typically result in a decrease in cellular energy production, accelerating the ageing processes and inducing important tissue alterations. The involvement of oxidative stress in the development of various pathological processes, including inner ear disorders and oral-facial pain, is now recognized. In this context, various molecules with antioxidant functions, such as alpha-lipoic acid (ALA) and acetyl L-carnitine (ALCAR), could be useful in inactivating free radicals and triggering chemical reactions to hinder the perpetuation of the inflammatory state.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available