Journal
AVICENNA JOURNAL OF PHYTOMEDICINE
Volume 12, Issue 4, Pages 439-448Publisher
MASHHAD UNIV MED SCIENCES
DOI: 10.22038/AJP.2022.19703
Keywords
Pomegranate seed oil; Tacrolimus; Nephrotoxicity; Cardiotoxicity
Categories
Funding
- Vice-Chancellor for Research and Technology, Mashhad University of Medical Sciences, Iran [970943]
Ask authors/readers for more resources
This research demonstrates that pomegranate seed oil has protective effects against the toxicity of tacrolimus, reducing renal and cardiac damage by scavenging free radicals.
Objective: The clinical use of tacrolimus is limited due to its side effects. This research investigated the protective activities of pomegranate seed oil (PSO) against TAC toxicity. Materials and Methods: The groups are included normal (1 ml of corn oil), TAC (2 mg/kg), and co-treatment of PSO (0.4 and 0.8 ml/kg) and TAC. All administrations were carried out intraperitoneally for 14 days. After the last injection, blood was collected from the heart. Results: TAC increased creatinine and urea. Increased malondialdehyde, reduced thiol content and superoxide dismutase. The elevation of lactate dehydrogenase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine kinase-MB and creatinine phosphokinase that confirmed cardiac toxicity. PSO reduced TAC toxicity. PSO decreased TAC-induced pathology injury. Conclusion: PSO reduced TAC toxicity in renal and heart via scavenging free radicals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available