4.1 Article

1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization

Journal

ARKIVOC
Volume -, Issue -, Pages 99-107

Publisher

ARKAT USA INC
DOI: 10.24820/ark.5550190.p011.685

Keywords

Halloysite nanotubes; 3-oligotriazole; covalent modification; Huisgen reaction; HNTs-prodrug

Funding

  1. University of Palermo

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The development of nano-formulations for cancer treatment is a major challenge in scientific research. Using the prodrug strategy with nanocarriers can improve the biological activity of drug molecules and reduce their side effects.
In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.

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